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digoxin-like factors

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cardenolide factors found in plasma which shares immunological determinants with digoxin and ouabain; high levels of endoxin correlated with hypertension

Also Known As:

digitalis-like factors; digoxin-immunoreactive factors; digoxin-like immunoreactive factor; digoxin-like immunoreactive substance; endalin; endogenous digitalis-like factor; endogenous digoxin-like factor; endoxin; ouabain-like factor; ouabain-like natriuretic factor

Networked: 139 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adair, C David: 4 articles (08/2013 - 02/2011)
2.	Ke, Yong-Sheng: 4 articles (02/2007 - 04/2003)
3.	Graves, Steven W: 3 articles (08/2013 - 02/2011)
4.	Adair, C D: 3 articles (04/2009 - 03/2009)
5.	Wang, De-Guo: 3 articles (02/2007 - 06/2004)
6.	Wang, He-Gui: 3 articles (02/2007 - 06/2004)
7.	Ferrandi, M: 3 articles (08/2001 - 03/2000)
8.	Manunta, P: 3 articles (08/2001 - 03/2000)
9.	Ke, Y S: 3 articles (03/2001 - 04/2000)
10.	Yoshika, Masamichi: 2 articles (06/2012 - 05/2011)

Related Diseases

1.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 11/01/2000 - "To evaluate the antihypertensive efficacy of angiotensin converting enzyme inhibitor (ACEI) benazepril in combination with AT1 receptor antagonist valsartan and their effect on left ventricular hypertrophy, renin angiotensin aldosterone system (RAAS) and endoxin in spontaneously hypertensive rat (SHR). "
2.	Hypertension (High Blood Pressure) 07/01/1989 - "The objective of this study was to measure maternal total digoxin-like immunoreactive factor levels in singleton pregnancies with or without hypertension and in twin pregnancies. " 01/01/1986 - "Chemical and clinical studies of endogenous digitalis-like factor in hypertension." 04/01/2003 - "The levels of plasma endoxin and Ang II in patients with essential hypertension were remarkably higher than those in normal subjects. " 08/01/2001 - "Moreover, basal levels of plasma ouabain-like factor do not differ among patients with salt-sensitive or salt-resistant hypertension. " 08/01/2001 - "An ouabain-like factor has been implicated repeatedly in salt-sensitive hypertension as a natriuretic agent. "
3.	Myocardial Infarction 01/01/1996 - "The main aim of the study was to test the hypotheses that (a) concentrations of endogenous digoxin-like factor (EDLF) are increased in the initial period after acute myocardial infarction (AMI) and (b) may contribute to the onset of ventricular arrhythmias. " 01/01/1994 - "The aim of the study was to test the hypotheses that the concentrations of endogenous digoxin-like factor (EDLF) are (i) increased in the initial period after acute myocardial infarction (AMI) and (ii) may contribute to the genesis of ventricular arrhythmias. " 01/01/1996 - "[Endogenous digoxin-like factor in myocardial infarction]." 01/01/1994 - "Endogenous digoxin-like factor in acute myocardial infarction." 01/01/1992 - "The authors examined endogenous digitalis-like factor (DLF) concentrations in the serum and urine in 65 patients with acute myocardial infarction. "
4.	Pre-Eclampsia (Preeclampsia) 01/01/1988 - "The objectives of this study were to evaluate the relationship between maternal digoxin-like immunoreactive substance and gestational age and compare digoxin-like immunoreactive substance concentrations in patients with and without preeclampsia who were in the third trimester. " 04/01/2012 - "Endogenous digitalis-like factors (EDLFs) appear to be hypertensiogenic and increased in the serum and placenta of women with preeclampsia (PE), a complication of pregnancy. " 04/01/2009 - "An endogenous digitalis-like factor (EDLF) has been implicated in the pathophysiology of preeclampsia (PE). " 03/01/2009 - "Preeclampsia is also associated with elevated endogenous digoxin-like factors (EDLFs). " 07/01/1989 - "We therefore conclude that digoxin-like immunoreactive factor does not contribute significantly to the pathogenesis or prediction of preeclampsia. "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2004 - "Although the level of plasma endoxin is significantly higher during myocardial ischemia, its practical significance is unclear. " 02/01/2007 - "[Effect of inhibiting endoxin by antidigoxin antiserum on myocardial ischemia/reperfusion injury in rats]." 07/01/2004 - "Endoxin antagonist lessens myocardial ischemia reperfusion injury." 06/01/2004 - "The results suggest that endoxin might be one of main factors mediating myocardial ischemia reperfusion injury." 06/01/2004 - "This research is to investigate whether endoxin is one of important factors involved in myocardial ischemia reperfusion injury. "

Related Drugs and Biologics

1.	valsartan (Vals)
2.	benazepril (Briem)
3.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
4.	Digoxin (Digitek)
5.	Sodium
6.	Ouabain (G Strophanthin)
7.	marinobufagenin
8.	Adenosine Triphosphatases (ATPase)
9.	Renin
10.	Potassium

Related Therapies and Procedures

1.	Surgical Instruments (Clip)
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
3.	Ligation