RP 40749

structure given in first source

Also Known As:

2-methylaminocarbothioyl-2-(pyridyl)-2-tetrahydrothiophene; 40749 RP; N-methyl-2-(2-pyridyl)-2,3,4,5-tetrahydro-2-thiophene carbothioamide; RP-40749; 2-Thiophenecarbothioamide, tetrahydro-N-methyl-2-(2-pyridinyl)-

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - RP 40749: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - RP 40749: 6

Related Diseases

1.	Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison) 06/01/1986 - "The efficacy of a new gastric antisecretory drug, 40749 RP, was studied in five cases of Zollinger-Ellison syndrome. " 06/01/1986 - "[Treatment of gastric acid hypersecretion in the Zollinger-Ellison syndrome with a thioamide derivative (40749 RP). "
2.	Duodenal Ulcer (Curling's Ulcer) 05/01/1986 - "Eleven patients with an endoscopically proven duodenal ulcer received 100 mg of 40749 RP at 8 PM for 3 wk and thereafter a placebo for an additional 3 wk study period. " 07/01/1985 - "Eighteen patients with active duodenal ulcer were treated with a novel antisecretory drug, RP 40749, either 100 mg or 150 mg as a daily nocturnal dose for 28 days. " 04/07/1984 - "RP 40749 in treatment of duodenal ulcer." 04/01/1986 - "Effects of single daily doses of a pyridil-2-tetrahydrothiophene derivative (40749 RP) on 24 hour H+ activity, nocturnal acid output, gastrin and pepsinogen I profiles in duodenal ulcer patients." 07/01/1985 - "Influence of RP 40749 on basal and meal-stimulated serum-gastrin, serum-pepsinogen I, and gastrin-content of the antral mucosa in duodenal ulcer patients."
3.	Peptic Ulcer (Peptic Ulcers) 05/01/1986 - "Acute and chronic 24-hour gastric pH and pharmacokinetic studies with a long acting antisecretory drug (40749 RP) in peptic ulcer." 02/01/1984 - "These results showed that 40749 RP is a potent antisecretory drug which could be of benefit in the treatment of peptic ulcer disease. "
4.	Ulcer 07/01/1985 - "All nine patients receiving 150 mg RP 40749 and eight of nine patients receiving 100 mg RP 40749 healed their ulcers completely within 28 days, becoming rapidly symptom-free after an average of three days. "
5.	Duodenitis 06/01/1986 - "In two cases, chronic duodenitis disappeared with 40749 RP only. "

Related Drugs and Biologics

1.	Pepsinogen A (Pepsinogen)
2.	Gastrins
3.	Thioamides
4.	Acids
5.	Antral