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muconaldehyde
potential toxic intermediate in benzene metabolism; structure given in first source
Also Known As:
2,4-Hexadienedial
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Aldehydes: 2153
muconaldehyde: 2
Related Diseases
1.
Leukemia
06/20/1997 - "
As the parent compound of t,t-MA, trans,trans-muconaldehyde is myelotoxic, and its production has been implicated in benzene-induced leukemia.
"
04/01/1997 - "
Increased gene expression in human promyeloid leukemia cells exposed to trans,trans-muconaldehyde, a hematotoxic benzene metabolite.
"
04/01/1997 - "
Because expression of the transcription factors AP-1 and NF-kappaB is sensitive to the redox state in eukaryotic cells, the DNA binding activity of AP-1 and NF-kappaB was examined in HL-60 promyeloid leukemia cells exposed to trans,trans-muconaldehyde, a microsomal hematotoxic metabolite of benzene.
"
Related Drugs and Biologics
1.
Benzene (Benzole)
2.
Transcription Factor AP-1 (Transcription Factor AP 1)
3.
NF-kappa B (NF-kB)
4.
Transcription Factors (Transcription Factor)
5.
DNA (Deoxyribonucleic Acid)