swerchirin

from Swertia tetrapetala Pall; structure given in first source

Also Known As:

1,8-dihydroxy-3,5-dimethoxy-xanthenone; 1,8-dihydroxy-3,5-dimethoxyxanthenone; 9H-Xanthen-9-one, 1,8-dihydroxy-3,5-dimethoxy-

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Xanthones: 211
        swerchirin: 5

Experts

1.	Luo, Lan: 2 articles (01/2021 - 01/2018)
2.	Luo, Qian: 2 articles (01/2021 - 01/2018)
3.	Zhao, Haibo: 2 articles (01/2021 - 01/2018)
4.	Barbosa, Ana Cristina Lopes: 1 article (02/2013)
5.	Bhowmik, Prasanta C: 1 article (02/2013)
6.	Jha, Pramod Kumar: 1 article (02/2013)
7.	Phoboo, Susanna: 1 article (02/2013)
8.	Pinto, Marcia Da Silva: 1 article (02/2013)
9.	Sarkar, Dipayan: 1 article (02/2013)
10.	Shetty, Kalidas: 1 article (02/2013)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2018 - "In the present study we evaluated the anticancer activity of swerchirin against human SKOV3 ovarian cancer cell line. " 01/01/2021 - "Retraction of: 'Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade', by Lan Luo, Haibo Zhao, Qian Luo, JBUON 2018;23(1):111-116; PMID:29552769. " 01/01/2018 - "Swerchirin exerts anticancer activity on SKOV3 human ovarian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade."
2.	Neoplasms (Cancer) 01/01/2021 - "Swerchirin exerts anticancer activity on SKOV3 human ovartian cancer cells via induction of mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of Raf/MEK/ERK cascade." 03/01/2005 - "In this study, the chemopreventive action of xanthone (XAN) derivatives (bellidifolin [BEL], gentiacaulein [GEN], norswertianin [NOR] and swerchirin [SWE]) on DNA damage photosensitized by riboflavin was demonstrated using [32P]-5'-end-labeled DNA fragments obtained from genes relevant to human cancer. "
3.	Hypersensitivity (Allergy) 01/01/2012 - "These plants compounds were selected because; parts of these plants are widely used againsts inflamation, allergy, asthma etc. Three metabolites of Swertia chirata namely Gentianine (GENT), Xanthone (XANT) and Swerchirin (SWER) are found to be occupying the same binding pocket in the LBD of the GR (PDB ID 1M2Z). "
4.	Hyperglycemia 02/01/2013 - "Although the anti-diabetic property of S. chirayita is mainly attributed to the phytochemical swerchirin present in its hexane fraction, we propose that the crude extract of this plant used in local healing also has anti-hyperglycemia potential. "
5.	Asthma (Bronchial Asthma) 01/01/2012 - "These plants compounds were selected because; parts of these plants are widely used againsts inflamation, allergy, asthma etc. Three metabolites of Swertia chirata namely Gentianine (GENT), Xanthone (XANT) and Swerchirin (SWER) are found to be occupying the same binding pocket in the LBD of the GR (PDB ID 1M2Z). "

Related Drugs and Biologics

1.	xanthone
2.	Riboflavin (Vitamin B2)
3.	DNA (Deoxyribonucleic Acid)
4.	gentiacaulein
5.	bellidifolin
6.	Mitogen-Activated Protein Kinase Kinases (MEKs)
7.	Phytochemicals
8.	Complex Mixtures
9.	Hexanes
10.	gentianine