FPL 57231

05/01/1985 - "Leukotriene inhibition with FPL 57231 may be useful in the management of infants with persistent pulmonary hypertension syndrome."
11/01/1985 - "In order to elucidate the role of leukotrienes in hypoxic pulmonary hypertension in a young animal model, the effects of a leukotriene antagonist, FPL 57231, were evaluated in anesthetized piglets. "

11/01/1985 - "In addition, pretreatment with FPL 57231 attenuated the hemodynamic response to hypoxia. "
11/01/1985 - "These measurements were compared during continued hypoxia between a control and treatment group which received FPL 57231. "
05/01/1985 - "The hypoxia-induced increase in cardiac output was maintained during the infusion of FPL 57231. "
05/01/1985 - "The infusion of FPL 57231 during hypoxia-induced pulmonary vasoconstriction reversed the increase in pulmonary arterial pressure (p less than 0.05) and pulmonary vascular resistance (p less than 0.05). "
09/01/1989 - "Similarly, the LT receptor antagonists FPL 57231 (3 microM) or LY 163443 (1 microM), at concentrations that inhibited LT-induced venular contractions, did not significantly affect the responses to hypoxia or anoxia. "

09/01/1988 - "In order to evaluate the role of leukotrienes in group B streptococcal (GBS) sepsis we studied the effect of a leukotriene receptor antagonist, FPL 57231, on the late hemodynamic changes occurring secondary to an infusion of live GBS. "
10/01/1986 - "In order to evaluate the influence of leukotrienes on group B streptococcal (GBS) sepsis we studied the effect of a leukotriene antagonist, FPL 57231, on the early hemodynamic changes occurring secondary to an infusion of live GBS. "

01/01/1987 - "We studied the effects of a selective leukotriene (LT) antagonist (FPL 57231, 2 mg kg-1 min-1) on the acute cardiopulmonary changes observed in feline endotoxin shock. "

09/01/1986 - "Indomethacin and FPL-57231 inhibit antigen-induced airway hyperresponsiveness in sheep."