FK 156

structure given in first source; RN given refers to ((L)(R)-isomer

Also Known As:

FK 156, (D)(R)-isomer; FK-156; Glycine, N-(2-hydroxy-1-oxopropyl)-L-alanyl-D-gamma-glutamyl-meso-alpha,epsilon-diaminopimelyl-, (R)-; Glycine, N-(2-hydroxy-1-oxopropyl)-L-alanyl-D-gamma-glutamyl-L-erythro-alpha,epsilon-diaminopimelyl-, (R)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 05/01/1983 - "Although significant life-span prolongation could not be seen in the two-injection regimen of six compounds in either system, systemic multiple injections of FK-156 and FR-46758 provided a statistically significant increase in the median survival time of P388 tumor bearing mice." 05/01/1983 - "These results indicate the superiority of FK-156 and FR-46758 as immunotherapeutic agents over FK-565 with respect to their safety for treatment of cancer. " 08/01/1983 - "FK-156 restored decreased counts and functions of phagocytes in mice immunosuppressed by cyclophosphamide, hydrocortisone or tumor. " 05/01/1983 - "Among 21 compounds tested, FK-156, FK-565, FR-46758, FR-48217, FR-46091 and FR-47920 substantially suppressed tumor growth when directly injected into a tumor mass and further experiments showed that FK-156, FK-565 and FR-46758 were effective even when administered subcutaneously into site remote from tumor. " 08/01/1983 - "The immunoactive peptides, FK-156 and its analogue, FK-565 were evaluated in various models of mice immunosuppressed with cyclophosphamide, hydrocortisone, mitomycin C, carrageenan and tumor cells. "
2.	Infections 08/01/1983 - "Treatment with FK-156 (subcutaneous) and FK-565 (oral) markedly restored host defense ability against microbial infection. " 08/01/1983 - "The enhancing effects of FK-156 and FK-565 on host defense of mice against pseudomonal infection was more potent than other immunoactive drugs." 08/01/1983 - "The therapeutic effect of these antibiotics against pseudomonal infection in immunosuppressed mice was enhanced markedly by combined use with FK-156. "
3.	Escherichia coli Infections 08/01/1983 - "The protective effect of these drugs against Escherichia coli infection differed considerably depending on the route of administration; FK-156 was only effective by the parenteral route; however, FK-565 was effective by both parenteral and oral routes. "
4.	Body Weight (Weight, Body) 05/01/1983 - "A single dose of FK-565, however, markedly decreased body weight in healthy DBA/2 mice, whereas FK-156 and FR-46758 did not. "

Related Drugs and Biologics

1.	heptanoyl- gamma- D- glutamyl- L- meso- diaminopimelyl- D- alanine
2.	Hydrocortisone (Cortisol)
3.	Cyclophosphamide (Cytoxan)
4.	Therapeutic Uses
5.	Mitomycin (Mitomycin-C)
6.	Peptides (Polypeptides)
7.	Carrageenan
8.	Anti-Bacterial Agents (Antibiotics)
9.	FR 48217

Related Therapies and Procedures

1.	Injections