catechol (pyrocatechol)

01/01/2012 - "It is not well understood which interactions of deleted genes in 22q11.2 regions are responsible for the pathogenesis of schizophrenia, but catechol-O-methytransferase (COMT) is among the candidates. "
03/01/2009 - "We investigated the catechol-O-methyltrasferase (COMT) gene, which is a strong functional and positional candidate gene for schizophrenia and therapeutic response to antipsychotic medication. "
01/01/2009 - "Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia."
12/09/2014 - "We have previously demonstrated a novel detection approach for this redox-active drug, highly effective in schizophrenia treatment, based on a catechol-modified chitosan film. "
04/01/2011 - "In this study, we aimed to assess the moderating effects of the catechol-O-methyl transferase (COMT) (Val(158/108)Met) genotype on antipsychotic medication-induced changes in the cognitive performance of patients with chronic schizophrenia. "

12/01/2008 - "The mechanisms of catechol-induced cytotoxicity were studied in cultures of neuroblastoma N2a cells. "
12/01/2008 - "Cytotoxic effects of catechol to neuroblastoma N2a cells."
03/01/2008 - "Characterization of catechol-thioether-induced apoptosis in human SH-SY5Y neuroblastoma cells."
10/01/1986 - "Hence, the human neuroblastoma cell lines studied appear to serve as appropriate models of catechol reuptake processes in noradrenergic cells."
10/01/1986 - "Human neuroblastoma cell lines as models of catechol uptake."

09/01/2005 - "Our results suggest that mouse lymphoma cells are somewhat more sensitive towards catechol-induced DNA damage than the extended-term cultures of human lymphocytes. "
09/01/2005 - "Different roles of Fpg and Endo III on catechol-induced DNA damage in extended-term cultures of human lymphocytes and L5178Y mouse lymphoma cells."
01/10/2004 - "Taken together, these data suggest that the genotoxic potential of pure trans-capsaicin is very low, especially as the clinical significance of weak mutagenicity in the mouse lymphoma assay for catechol-moiety containing compounds is unclear. "
09/01/2013 - "The aim of the present study was to evaluate the potential protective effects of a physiologically relevant concentration (2 μM) of β-carotene on the DNA damaging effects of catechol in mouse lymphoma L5178Y cells. "
03/01/2009 - "Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells."

01/03/1997 - "Aneuploidy in the near diploid range of SHE cells was significantly induced by benzene and catechol. "
01/15/1990 - "The higher efficacy of hydroquinone in inducing both total micronuclei and kinetochore-positive micronucleated cells when compared with catechol, phenol, and 1,4-benzoquinone suggests that hydroquinone is a major contributor to the clastogenicity and aneuploidy observed in the lymphocytes of benzene-exposed workers. "
01/03/1997 - "Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells."

02/01/1962 - "The release and depletion of catechol amines by reserpine show little likelihood of being responsible for protection because these substances are in themselves protective against anaphylactic shock, while beta-TM 10, a drug which interferes with their release is not. "