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isocitric acid (isocitrate)

Subscribe to New Research on isocitric acid

RN given refers to unlabeled parent cpd

Also Known As:

isocitrate; isocitric acid, (11)C-labeled; isocitric acid, calcium salt; isocitric acid, disodium salt; isocitric acid, potassium salt; isocitric acid, sodium salt; isocitric acid, trisodium salt

Networked: 124 relevant articles (1 outcomes, 7 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Acyclic Acids
    - Tricarboxylic Acids: 4
      - Citrates: 31
        Isocitrates
        isocitric acid: 124

Experts

1.	Su, Shinsan M: 5 articles (03/2014 - 09/2010)
2.	Bigner, Darell D: 4 articles (12/2012 - 02/2009)
3.	Yan, Hai: 4 articles (12/2012 - 02/2009)
4.	Choi, Bu Young: 3 articles (12/2015 - 03/2015)
5.	Keum, Young-Sam: 3 articles (12/2015 - 03/2015)
6.	Bovée, Judith V M G: 3 articles (01/2015 - 01/2013)
7.	Rakheja, Dinesh: 3 articles (01/2015 - 03/2011)
8.	French, Pim J: 3 articles (10/2013 - 01/2011)
9.	von Deimling, Andreas: 3 articles (01/2013 - 08/2010)
10.	Jin, Genglin: 3 articles (12/2012 - 02/2009)

Related Diseases

1.	Anemia 01/01/2016 - "Isocitrate treatment of acute anemia of inflammation in a mouse model." 08/01/2013 - "Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response." 08/01/2013 - "Here, we show that suppression of the erythroid iron restriction response by isocitrate administration corrected anemia and erythropoietic defects in rats with ACDI. " 07/08/2010 - "Exogenous isocitrate abrogated the erythroid iron restriction response in vitro and reversed anemia progression in iron-deprived mice. "
2.	Glioma (Gliomas) 05/01/2015 - "The identification of mutations in the gene encoding isocitrate dehydrogenase‑1 (IDH1) represents a key area of investigation in studies on glioma. " 08/01/2015 - "Imaging Markers of Isocitrate Dehydrogenase-1 Mutations in Gliomas." 05/01/2015 - "Overexpression of isocitrate dehydrogenase-1R¹³²H enhances the proliferation of A172 glioma cells via aerobic glycolysis." 10/01/2014 - "A monoclonal antibody (clone HMab-1) that specifically and sensitively recognizes the isocitrate dehydrogenase-1 (IDH1) protein carrying the R132H mutation can identify invading glioma cells by immunostaining. " 10/01/2013 - "Recently, it was shown that somatic isocitrate dehydrogenase-1 (IDH1) mutations, frequently observed in gliomas, establish CIMP in primary human astrocytes by remodeling the methylome. "
3.	Astrocytoma (Pilocytic Astrocytoma) 09/01/2015 - "To establish an accurate subclassification of low-grade gliomas, we retrospectively evaluated isocitrate dehydrogenase-1 (IDH1) mutation in clinical specimens of diffuse astrocytomas (DA) and oligodendroglial tumors separately. " 09/01/2014 - "To study the putative expression patterns and clinical significance of Hsp27, we assessed the associations between Hsp27, R132H mutation of Isocitrate dehydrogenase1 (IDH1-R132H), Hypoxia-inducible factor subunit alpha (HIF-1 alpha), Carbonic anhydrase IX (CA IX), and patient prognosis in astrocytic gliomas. " 01/01/2015 - "Recent genetic studies have revealed that the major categories of gliomas, such as circumscribe astrocytomas, infiltrating astrocytomas/oligodendrogliomas, and glioblastoma, roughly correspond to major genetic alterations, including isocitrate dehydrogenases (IDHs) 1/2 mutations, TP53 mutations, co-deletion of chromosome arms 1p/19q, and BRAF mutation/fusion. " 01/01/2015 - "Recent genetic studies have revealed that the major categories of gliomas, such as circumscribe astrocytomas, infiltrating astrocytomas/oligodendrogliomas, and glioblastoma, roughly correspond to major genetic alterations, including isocitrate dehydrogenases (IDHs) 1/2 mutations, TP53 mutations, co-deletion of chromosome arms 1p/19q, and BRAF mutation/fusion. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2014 - "Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia." 12/01/2013 - "An isocitrate dehydrogenase1 (IDH1) mutation, affecting codon132 of the isocitrate dehydrogenase1 gene, has prognostic significance in glioblastomas. " 12/01/2013 - "Correlation between the prognostic value and the expression of the stem cell marker CD133 and isocitrate dehydrogenase1 in glioblastomas." 02/01/2011 - "Recent advances in clinical medicine have elucidated two significantly different subtypes of glioblastoma which carry very different prognoses, both defined by mutations in isocitrate dehydrogenase-1 (IDH-1). " 01/01/2011 - "The discovery of somatic mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) in glioblastomas was remarkable because the enzyme was not previously identified with any known oncogenic pathway. "
5.	Oligodendroglioma 11/01/2011 - "Proteomic analysis of oligodendrogliomas expressing a mutant isocitrate dehydrogenase-1." 05/01/2013 - "We present 9 pediatric cases of such diffuse leptomeningeal neuroepithelial tumors (DLNT), 8 with assessment of 2 common genetic alterations seen in oligodendrogliomas, 1p and 19q chromosomal deletions and isocitrate dehydrogenase-1 (IDH1) R132H mutations. " 07/01/2012 - "Of these, the use of mutated isocitrate dehydrogenase-1 (IDH-1) as a marker of diffuse infiltrating astroctomas, oligodendrogliomas, and a subset of glioblastomas (secondary glioblastomas) is particularly exciting for tissue diagnosis and patient prognosis. " 11/01/2011 - "Isocitrate dehydrogenase-1 (IDH1) mutation is frequent in diffuse gliomas such as oligodendrogliomas. " 01/01/2015 - "Recent genetic studies have revealed that the major categories of gliomas, such as circumscribe astrocytomas, infiltrating astrocytomas/oligodendrogliomas, and glioblastoma, roughly correspond to major genetic alterations, including isocitrate dehydrogenases (IDHs) 1/2 mutations, TP53 mutations, co-deletion of chromosome arms 1p/19q, and BRAF mutation/fusion. "

Related Drugs and Biologics

1.	Iron
2.	Oxidoreductases
3.	Carbon Monoxide
4.	Arginine (L-Arginine)
5.	Serine (L-Serine)
6.	Carbonic Anhydrases (Carbonic Anhydrase)
7.	NADP (NADPH)
8.	Citric Acid (Citrate)
9.	malic acid (malate)
10.	Succinic Acid (Succinate)

Related Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy)