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pirenperone
Also Known As:
3-(2-(4-(4-fluorobenzoyl)piperidino)ethyl)-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one; R 47456; R 50656; R-47456; R-50656; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-2-methyl-
Networked:
14
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
pirenperone: 14
Related Diseases
1.
Lordosis
07/01/1986 - "
Harmine reverses the inhibition of lordosis by the 5-HT2 antagonists pirenperone and ketanserin in the female rat.
"
05/01/1987 - "
The suppressive effects on the lordosis behaviour by 8-OH-DPAT cannot be antagonized by the DA receptor antagonist haloperidol (0.2 mg X kg-1) neither with methiotepin (0.5 mg X kg-1), which is assumed to be a non-selective 5-HT receptor blocking agent, nor with pirenperone (0.25 mg X kg-1) which is assumed to be a 5-HT2 receptor blocking agent.
"
01/01/1989 - "
The suppression of lordosis produced by 5-HTP was antagonized by the beta-receptor blocker (-)pindolol, which also is a selective 5-HT1 receptor antagonist, but not by the 5-HT2 receptor antagonists metitepine or pirenperone, nor by the beta-receptor blocker betaxolol.
"
07/01/1986 - "
Moreover, harmine reversed the inhibition of lordosis by the serotonin type 2 (5-HT2) antagonists pirenperone and ketanserin in rats primed with estradiol benzoate and progesterone.
"
2.
Panic Disorder (Panic Attack)
06/01/1995 - "
In view of previous results indicating that the panic-promoting drug yohimbine increases flight/escape reactions and that the panicolytic compound alprazolam reduces these responses, we tentatively suggest that the preferential 5-HT2A receptor antagonist pirenperone may have some efficacy in improving panic attacks.
"
3.
Tremor (Tremors)
01/01/1987 - "
ICS 205-930 and MDL 72222 were more than 1000 times less potent than pirenperone or methysergide and 100 times less potent than ketanserin in blocking 5-MeODMT-induced forepaw treading and tremor.
"
4.
Myoclonus (Nocturnal Myoclonus)
01/01/1986 - "
S2 antagonists inhibited limb (arrhythmic and asynchronous) and axial (truncal) myoclonus in a dose-dependent manner in the rank order of potency: pirenperone greater than pipamperone greater than ketanserin = cinanserin.
"
5.
Hypotension (Low Blood Pressure)
01/01/1985 - "
The cardiovascular effects of 8-OH-DPAT were not prevented by pretreatment with methergoline, methiothepin, pirenperone or cianserine or by 5-HT depletion by means of p-chlorophenylalanine, which suggests that the putative 5-HT receptor that is responsible for the hypotension and bradycardia to 8-OH-DPAT is not of a presynaptic type and does not have the pharmacological characteristics of a general 5-HT1 receptor.
"
Related Drugs and Biologics
1.
Ketanserin
2.
5-HT1 Serotonin Receptors
3.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
4.
Serotonin (5 Hydroxytryptamine)
5.
Serotonin Receptors
6.
Methiothepin
7.
Cinanserin
8.
Serotonin 5-HT2 Receptor Antagonists
9.
5-HT2A Serotonin Receptor (5 HT2A Receptor)
10.
Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
Related Therapies and Procedures
1.
Induced Hyperthermia (Thermotherapy)