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Sch 29482
penem antibiotic; bactericidal & stable to beta-lactamases; structure given in first source
Also Known As:
6-(1-hydroxyethyl)-2-ethylthiopenem-3-carboxylic acid; Sch-29482; 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(ethylthio)-6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Lactams: 2198
Sch 29482: 2
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Lactams: 2198
Sch 29482: 2
Related Diseases
1.
Infections
09/01/1984 - "
Treatment of animals with the lower dose of Sch 29482 represented borderline or suboptimal therapy, with a failure rate of one in four for each infection model.
"
01/01/1991 - "
Overall, the combination of ceftibuten and SCH 29482 at concentrations that can be achieved in serum after ingestion of 400 and 50 micrograms/ml, respectively, provided antibacterial activity against most Gram-positive aerobic and anaerobic species that cause upper respiratory, intraabdominal, and urinary infections.
"
09/01/1984 - "
In both infection models, striking differences were noted between the untreated control rabbits and rabbits receiving penicillin G benzathine or high-dose Sch 29482.
"
09/01/1984 - "
Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection.
"
09/01/1984 - "
The present study was designed to assess the in vivo activity of Sch 29482, a new penem antibiotic, against disseminated and localized Treponema pallidum infections in rabbits.
"
2.
Syphilis
09/01/1984 - "
Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection.
"
3.
Body Weight (Weight, Body)
09/01/1984 - "
Randomized groups then received 25 or 50 mg of Sch 29482 per kilogram of body weight twice a day for 7 days, two weekly injections of 200,000 U of penicillin G benzathine for comparative purposes, or no antibiotic therapy.
"
Related Drugs and Biologics
1.
Anti-Bacterial Agents (Antibiotics)
2.
Meropenem (Merrem)
3.
Penicillin G Benzathine (Benzathine Benzylpenicillin)
4.
Ceftibuten (Cedax)
Related Therapies and Procedures
1.
Therapeutics
2.
Injections