ethyl 2- (5- (4- chlorophenyl)pentyl)oxiran- 2- carboxylate (POCA)

01/01/1988 - "In hearts of CD rats insulin resistance is not dependent on disturbances in lipid metabolism and is practically not influenced by POCA. "
01/01/1988 - "In hearts of AD rats an absolute insulin resistance was observed which could be attenuated by perfusion of the hearts with POCA (10 microM). "
01/01/1988 - "The insulin resistance can be eliminated and has to be distinguished from a defect in the glucose uptake system not affected by POCA. "
02/01/1984 - "(2) Since in vitro perfusion with POCA partially restored the insulin sensitivity of the diabetic hearts, insulin-receptor defects should be of minor importance for the insulin resistance of diabetic hearts. "
01/01/1988 - "In hearts of CD rats, which show a relative insulin resistance, POCA only slightly stimulated glucose oxidation and uptake, but the total rate of uptake and conversion of glucose as well as the responsiveness of these hearts to insulin remained low. "

08/07/2021 - "A significant reduction in neointimal hyperplasia was observed after implanting POCA-coated ePTFE vascular grafts in a guinea pig aortic interposition bypass graft model. "
09/01/2014 - "Finally, preliminary data on POCA-coated ePTFE grafts showed reduced intimal hyperplasia when compared to standard ePTFE grafts. "
08/07/2021 - "A bioactive POCA elastomer (@20 : 20 : 8, [citrate] : [diol] : [ascorbate]) coating was applied on a 1.5 mm diameter ePTFE vascular graft as the most promising therapeutic candidate for reducing neointimal hyperplasia. "

01/01/2023 - "ANTECEDENTES: A pesar de las influencias conocidas de los factores relacionados con la raza y el envejecimiento en los resultados y la mortalidad del cáncer colorectal, hay muy poca literatura sobre la intersección entre los impedimentos relacionados con la raza y el envejecimiento.OBJETIVO: El objetivo era explorar las diferencias raciales en los subdominios de fragilidad y déficit geriátrico entre los pacientes con cáncer colorectal.DISEÑO: Estudio retrospectivo utilizando datos del registro Cancer and Aging Resilience Evaluation.AJUSTES: Un centro oncológico integral en el Sur Profundo.PACIENTES: Adultos mayores (≥60 años) con cáncer colorrectal de raza Negra o Blanca.PRINCIPALES MEDIDAS DE RESULTADO: Medida compuesta de fragilidad y subdominios de evaluación geriátrica de función física, estado funcional, quejas cognitivas, función psicológica y calidad de vida relacionada con la salud.RESULTADOS: De los 304 pacientes incluidos, el 21,7% (n = 66) eran negros y la edad media era de 69 años. "
06/01/2021 - "CONCLUSIONES E IMPORTANCIA CLÍNICA: los CIPs se observan con poca frecuencia, por lo general como una sola lesión sin recidivas, aunque un grupo de perros con inmunodeficiencia combinada grave desarrolló neoplasias malignas invasivas. "
01/01/2021 - "Otra evidencia indicó que puede haber poca diferencia en la supervivencia con los campos de tratamiento del tumor en comparación con la mejor opción de tratamiento del médico. "
01/01/2021 - "Debido a la rareza de esta neoplasia existe poca experiencia en relación con el mejor manejo con impacto significativo en la supervivencia de los pacientes."
10/01/2019 - "Existe poca experiencia de la linfadenectomía guiada por ICG en tumor de vejiga. "

03/01/1989 - "The present study was performed to determine whether POCA could prevent accumulation of both LCA and LPC induced by ischemia in vivo and if so, whether attenuation of early arrhythmogenesis would result. "
09/01/1988 - "However, during ischemia, it is likely that the depletion of ATP concentration induced by POCA resulted in delayed recovery of mechanical function on reperfusion."
09/01/1988 - "During the ischemic period, though, POCA decreased the ATP concentration at a rate three times that of controls during the first 10 min. No further reductions were observed for up to 30 min of ischemia. "
03/01/1986 - "POCA may protect the ischemic heart by preventing accumulation of these toxic metabolites and by stimulating glucose utilization during ischemia."
03/01/1986 - "Short-chain acylcarnitine levels were increased during ischemia by POCA. "

01/01/2022 - "Sixty-five patients (4.7%) underwent POCA within 48 h after surgery due to suspected myocardial ischemia, representing the final study population. "