spergualin

from bacillus isolated from soil sample collected at Ohira-san

Also Known As:

1-amino-19-guanidino-11,15-dihydroxy-4,9,12-triazanonadecane-10,13-dione; Heptanamide, 7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-3-hydroxy-

Networked: 11 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - spergualin: 11

Experts

1.	Carolan, James P: 1 article (05/2011)
2.	Evans, Christopher G: 1 article (05/2011)
3.	Gestwicki, Jason E: 1 article (05/2011)
4.	Smith, Matthew C: 1 article (05/2011)

Related Diseases

1.	Leukemia 03/01/1987 - "It was shown to have chemotherapeutic effects on mice inoculated with various mouse leukemias such as L-1210 (IMC), L-1210, P388, P815, C1489, EL4 and RL male 1. Among these, spergualin was especially effective against L-1210 (IMC) tumors, where the mice were completely cured at an appropriate drug dosage. " 12/01/1991 - "A novel antitumor antibiotic, spergualin, is effective against various mouse leukemias. " 10/01/1986 - "Spergualin (SGL), a novel antitumor antibiotic, exhibited strong antitumor activity against transplantable leukemias in mice: L1210, L1210(IMC), P388, P815, C1498, EL-4 and RL male 1. It also exhibited antitumor activity against M5076 fibrosarcoma, AH66 and AH66F rat hepatomas, but not against Meth-A fibrosarcoma, B16 melanoma, Lewis lung carcinoma (LL) and C26 colon adenocarcinoma. "
2.	Neoplasms (Cancer) 03/01/1987 - "These cured mice rejected the second challenge of L-1210, but not other tumors, indicating that specific immunity had been induced by spergualin. " 05/01/2011 - "Spergualin is a natural product that exhibits immunosuppressive, anti-tumor and anti-bacterial activities. " 06/15/1987 - "administration of spergualin for 9 days at 5 mg/kg/day, which was started 1 day after the tumor inoculation. " 03/01/1987 - "These results suggest that the induction of tumor-immunity plays an important role in the antitumor activity of spergualin." 03/01/1987 - "It was shown to have chemotherapeutic effects on mice inoculated with various mouse leukemias such as L-1210 (IMC), L-1210, P388, P815, C1489, EL4 and RL male 1. Among these, spergualin was especially effective against L-1210 (IMC) tumors, where the mice were completely cured at an appropriate drug dosage. "
3.	Lewis Lung Carcinoma 10/01/1986 - "Spergualin (SGL), a novel antitumor antibiotic, exhibited strong antitumor activity against transplantable leukemias in mice: L1210, L1210(IMC), P388, P815, C1498, EL-4 and RL male 1. It also exhibited antitumor activity against M5076 fibrosarcoma, AH66 and AH66F rat hepatomas, but not against Meth-A fibrosarcoma, B16 melanoma, Lewis lung carcinoma (LL) and C26 colon adenocarcinoma. "
4.	T-Cell Leukemia (Leukemia, T Cell) 12/01/1991 - "Spergualin treatment-dependent delayed relapse of mouse T cell leukemia (DL812) after chemotherapy."
5.	Experimental Melanoma 10/01/1986 - "Spergualin (SGL), a novel antitumor antibiotic, exhibited strong antitumor activity against transplantable leukemias in mice: L1210, L1210(IMC), P388, P815, C1498, EL-4 and RL male 1. It also exhibited antitumor activity against M5076 fibrosarcoma, AH66 and AH66F rat hepatomas, but not against Meth-A fibrosarcoma, B16 melanoma, Lewis lung carcinoma (LL) and C26 colon adenocarcinoma. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	gusperimus
3.	Polyamines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)