fenarimol

12/01/1986 - "Studies to elucidate the mechanism of fenarimol-induced infertility in male rats."
11/01/1987 - "These data indicate that the decrease in male sexual behavior and the infertility associated with exposure to fenarimol were, most likely, due to inhibition of aromatase activity within the central nervous system."
11/01/1987 - "Inhibition of central nervous system aromatase activity: a mechanism for fenarimol-induced infertility in the male rat."
07/01/1987 - "Efforts to develop a novel class of nonsteroidal aromatase inhibitors began with the discovery that the infertility in male rats exposed to high levels of the agricultural fungicide, fenarimol (alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidine-methanol), was attributable to the inhibition of aromatase activity within the central nervous system during the critical neonatal period. "

05/10/2012 - "Chemical and biological studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported."
12/27/2013 - "Two analogues of fenarimol show curative activity in an experimental model of Chagas disease."
05/10/2012 - "Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease."

09/10/2011 - "Fenarimol-exposed F1 mice had shortened AGDs, increased body weight with altered organ weights, increased number of pups, increased number of ovarian follicles, and enhanced sperm quality. "
09/10/2011 - "Pregnant mice were orally exposed to low doses (0, 2, 20, and 200 μg/kg body weight) of fenarimol during gestational and lactational periods, and their offspring were assessed. "
01/01/1991 - "Liver enlargement achieved maximum growth by 3 or 5 days from first administration of 125 and 250 mg fenarimol/kg body weight per day, respectively. "
01/01/1990 - "Degenerative changes were observed in liver of rats treated with single and repeated doses of fenarimol (250 mg/kg body weight x day). "
01/01/1991 - "Fenarimol administered in one single or repeated oral doses of 250 or 125 mg/kg body weight per day, respectively, stimulated rat liver enlargement which was associated with a wave of DNA synthesis on the first day after start of treatment. "

02/28/2004 - "Fenarimol did not increase the number of chromosome aberrations significantly, but it reduced the mitotic index at the higher doses (P < 0.05). "
11/01/1991 - "Induction of numerical chromosomal aberrations during DNA synthesis using the fungicides nimrod and rubigan-4 in root tips of Vicia faba L."

05/01/1996 - "Genetic and non-genetic biomarkers related to carcinogenesis in evaluating toxicological risk from Fenarimol."