lolitrem B

neurotoxin from staggers-producing ryegrass pastures; MF C42-H55-N-O7

Also Known As:

7H-(1,3)Dioxino(5'',4'':3'3')oxireno(4',4'a)(1)benzopyrano(5',6':6,7)indeno(1,2-b)isobenzofuro(5,6-e)indol-13(8H)-one, 1,4a,4b,5b,6,7a,9,9a,10,12,12a,16,16b,16c,17,18,18a,19a-octadecahydro-5b-hydroxy-1,1,10,10,12,12,16b,16c-octamethyl-3-(2-methyl-1-propenyl)-

Networked: 15 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Guthridge, Kathryn: 2 articles (01/2020 - 01/2019)
2.	Read, Elizabeth: 2 articles (01/2020 - 01/2019)
3.	Reddy, Priyanka: 2 articles (01/2020 - 01/2019)
4.	Rochfort, Simone: 2 articles (01/2020 - 01/2019)
5.	Spangenberg, German: 2 articles (01/2020 - 01/2019)
6.	Combs, M D: 2 articles (11/2019 - 10/2019)
7.	Quinn, J C: 2 articles (11/2019 - 10/2019)
8.	Dalziel, Julie E: 2 articles (03/2009 - 12/2008)
9.	Dunlop, James: 2 articles (03/2009 - 12/2008)
10.	Finch, Sarah C: 2 articles (03/2009 - 12/2008)

Related Diseases

1.	Tremor (Tremors) 01/16/2020 - "Based on structure-activity postulations, six of these may contribute towards the protracted tremors exhibited by lolitrem B-exposed animals." 10/01/2019 - "Together these data indicate that the tremor exhibited by lolitrem B intoxicated mice does not directly impair spatial learning and memory but that exposure does reduce voluntary motor activity in intoxicated animals. " 10/01/2019 - "A single exposure to a known tremorgenic dose of lolitrem B (2 mg/kg IP) induced measureable tremor for up to 72 h in some animals. " 10/01/2019 - "In order to define the role of lolitrem B in voluntary motor control, spatial learning and memory under controlled conditions, mice were exposed to a known dose of purified lolitrem B toxin and tremor, coordination, voluntary motor activity and spatial learning and memory assessed. " 01/01/2019 - "Marked differences were observed in the duration of tremor and coordination between lolitrem B pathway members, with some showing protracted effects and others none at all. "
2.	Ataxia (Dyssynergia) 10/01/2019 - "Beside ataxia, lolitrem B intoxicated animals frequently show indicators of cognitive dysfunction or exhibition of erratic and unpredictable behaviours during handling. " 05/01/2012 - "The clinical effects of lolitrem B intoxication in horses primarily involve action-related tremors and symmetrical vestibular ataxia. " 05/01/2012 - "All horses developed a variable degree of tremor and ataxia when exposed to lolitrem B. " 12/01/2008 - "Unexpectedly, when the response to lolitrem B was examined in mice lacking the beta4 BK channel accessory subunit (Kcnmb4(-/-)), only low-level ataxia was observed. " 11/01/2019 - "Conclusions and clinical relevance: A single oral dose of 300 mg/kg bromide in lambs with neurological signs of PRGT resulted in reduced composite gait scores and reduced RMS voltages, indicating a significant improvement in clinical signs of ataxia, movement disorder and muscle tremor associated with the neurotoxic effects of lolitrem B."
3.	Movement Disorders (Movement Disorder) 11/01/2019 - "Conclusions and clinical relevance: A single oral dose of 300 mg/kg bromide in lambs with neurological signs of PRGT resulted in reduced composite gait scores and reduced RMS voltages, indicating a significant improvement in clinical signs of ataxia, movement disorder and muscle tremor associated with the neurotoxic effects of lolitrem B."
4.	Infections 04/01/2001 - "Unfortunately, a side effect of endophyte infection can be the production of alkaloids, including Lolitrem B and ergovaline, that produce toxic effects in animals. " 12/01/2008 - "It is caused by infection of perennial ryegrass pastures by an endophytic fungus that produces neurotoxins, predominantly the indole-diterpenoid compound lolitrem B. " 03/31/2020 - "In this study, we tested 24 commercially available seed mixtures for their infection rates with Epichloë endophytes and measured the concentrations of the alkaloids ergovaline, lolitrem B, paxilline, and peramine. "
5.	Body Weight (Weight, Body) 01/16/2020 - "Mice were administered lolitrem B at 0.5 and 2.0 mg/kg body weight (b.wt) intraperitoneally before body and brain tissues were collected at 6 h and 24 h post-treatment. " 01/01/2013 - "These results suggest that a daily intake of 18 µg kg(-1) body weight of lolitrem B can produce ryegrass staggers in Japanese black steers. "

Related Drugs and Biologics

1.	Bromides
2.	Alkaloids
3.	ergovaline
4.	paxilline
5.	Neurotransmitter Agents (Neurotransmitter)
6.	peramine
7.	Neurotoxins
8.	Diterpenes
9.	indole
10.	Mycotoxins

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