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ICI 105552
RN given refers to Na salt
Also Known As:
1-((3,4-dichlorobenzyl)-3-methyl)-1,2-dihydro-2-oxoquinol-4-ylacetate; 2,4-Cyclohexadien-1-one, 3-(acetyloxy)-6-((3,4-dichlorophenyl)methyl)-6-hydroxy-2-methyl-; I.C.I. 105552; ICI105552; 4-Quinolineacetic acid, 1-((3,4-dichlorophenyl)methyl)-1,2-dihydro-3-methyl-2-oxo-, sodium salt
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Quinolones: 2938
ICI 105552: 3
Related Diseases
1.
Body Weight (Weight, Body)
05/01/1983 - "
Treatment with ICI 105552 produced small (less than or equal to 11%) yet statistically significant increases in the weights of the kidneys, and both liver and kidney weight/100 g residual body weight but did not affect the weights of the body, lens, retina or S.V.C.G.
"
11/01/1983 - "
To test the possible involvement of the sorbitol pathway in the pathogenesis of retinopathy in long-term experimentally-diabetic rats, streptozotocin-diabetic and normal rats were dosed orally (50 mg/kg body weight daily) for up to 373 days with an aldose reductase inhibitor (ICI 105552) or a placebo.
"
05/01/1983 - "
For 22 days, streptozotocin-diabetic and normal rats were intubated once daily with ICI 105552 (1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid, sodium salt: 50 mg/kg body weight) an inhibitor of aldose reductase (EC 1.1.1.21), the first enzyme of the sorbitol pathway.
"
2.
Diabetic Retinopathy (Retinopathy, Diabetic)
05/01/1983 - "
(1) demonstrated that ICI 105552 was a potent inhibitor of aldose reductase in sciatic nerve and suggested that a proportion of nerve lactate in diabetes could result from sorbitol pathway activity; (2) implied that flux through the sorbitol pathway, eventually to form lactate, increases in diabetic retina; and (3) indicated, by the drug's reduction of retinal lactate concentration, that inhibitors of aldose reductase might be of potential use in diabetic retinopathy.
"
Related Drugs and Biologics
1.
Sorbitol (Yal)
2.
Aldehyde Reductase (Aldose Reductase)
3.
Streptozocin (Streptozotocin)
4.
Lactic Acid (Lactate)
5.
Sodium
6.
Salts
7.
Retinaldehyde (Retinal)
8.
Enzymes
9.
Acids