preproenkephalin

01/01/2009 - "Together, our results with HSV vectors encoding preproenkephalin demonstrated physiological improvement in visceral pain induced by bladder irritation. "
07/01/2014 - "Here we exploited a rat footpad model of PHN to show that herpes simplex virus (HSV) vector-mediated gene delivery of human preproenkephalin (vHPPE) effectively reduced chronic VZV-induced nocifensive indicators of pain. "
06/01/2001 - "Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE)."
03/04/1999 - "Expression of the human prodynorphin gene, which is involved in memory acquisition and pain, is regulated through its downstream regulatory element (DRE) sequence, which acts as a location-dependent gene silencer. "
12/01/1998 - "Induction of the prodynorphin gene has been implicated in medium and long-term adaptation during memory acquisition and pain. "

07/10/2000 - "We have used preproenkephalin (PPNK)-deficient mice to study the role of PPNK in the development of airway inflammation. "
04/01/2001 - "Furthermore, these data indicate that the suppression of the inflammation-induced increase in spinal cord prodynorphin is caused by the opioid-mediated decrease in the nociceptive stimulus."
01/01/1998 - "We propose a model in which inflammation-induced phosphorylation of CREB relieves CREB repression at the DYNCRE3 site, P-CREB binds to the c-Fos promoter, and Fos/Fra, P-CREB, and P-c-Jun interact at the DYNCRE3 site to activate prodynorphin gene transcription."
11/01/1994 - "The effects of glucocorticosteroid treatment on the basal and inflammation-induced prodynorphin expression were evaluated. "
06/01/1994 - "During chronic pain and inflammation, prodynorphin gene expression is elevated in the spinal cord. "

10/01/1996 - "These observations suggest that, at variance with other experimental situations, Fos is not involved in the mechanisms of kindled seizure-induced activation of prodynorphin transcription in the rat forebrain."
04/01/1995 - "There were no changes in preproenkephalin message in kindled animals studied after the one month seizure-free interval. "
04/01/1995 - "The change in prodynorphin message expression in cornu Ammonis regio superior persisted in kindled animals that were studied after one month seizure-free period. "
11/01/1992 - "Hence seizure-related changes in hippocampal prodynorphin neuron activity seem to depend on the experimental model of epilepsy.(ABSTRACT TRUNCATED AT 250 WORDS)"
10/05/1987 - "In rats exhibiting stage 4 seizures, the levels of prodynorphin mRNA in the dentate gyrus were dramatically reduced compared to control animals. "

05/08/2002 - "Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse."
11/05/2005 - "Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence."
05/08/2002 - "Our results suggest that this allelic variation at the promoter region of the prodynorphin gene (alleles with three or four repeats), which may result in enhanced transcription of the gene, may contribute to relative protection and decrease individual vulnerability to develop cocaine dependence or abuse."
04/01/2009 - "We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. "
09/01/1993 - "Using a quantitative solution hybridization protection assay for mRNA, we detected a significant increase in the concentration of prodynorphin mRNA in caudate putamen extracts of rats injected with cocaine following a 'binge' administration pattern designed to mimic human cocaine abuse. "

04/01/2009 - "The efficacy of a replication defective Herpes (HSV-1, DPE) viral vector construct encoding the human preproenkephalin gene (HSV-Enk), used as a molecular therapy for alleviation of pancreatitis pain, is reviewed here. "