1- (4- (trimethylamino)phenyl)- 6- phenylhexa- 1,3,5- triene

fluorescence probe for lipid bilayers

Also Known As:

1-(4-(trimethylamino)phenyl)-6-phenyl-1,3,5-hexatriene p-toluene sulfonate; 1-(4-(trimethylammonio)phenyl)-6-phenyl-1,3,5-hexatriene; TMA-DPH; trimethylammonium-diphenylhexatriene; Benzenaminium, N,N,N-trimethyl-4-(6-phenyl-1,3,5-hexatrienyl)-

Networked: 28 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        Diphenylhexatriene: 67
        1-(4-(trimethylamino)phenyl)-6-phenylhexa-1,3,5-triene: 28

Experts

1.	Mazzanti, Laura: 1 article (04/2008)
2.	Moroni, Cinzia: 1 article (04/2008)
3.	Nanetti, Laura: 1 article (04/2008)
4.	Provinciali, Leandro: 1 article (04/2008)
5.	Raffaelli, Francesca: 1 article (04/2008)
6.	Silvestrini, Mauro: 1 article (04/2008)
7.	Vignini, Arianna: 1 article (04/2008)
8.	Bkaily, Ghassan: 1 article (11/2006)
9.	Cauchon, Nicole: 1 article (11/2006)
10.	Hunting, Darel: 1 article (11/2006)

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/01/1999 - "Our dynamic fluorescence study showed a different microenvironmental organization of the cellular membrane after incubation with plasma from IDDM pregnant women, with a marked decrease in microheterogeneity as evaluated in terms of 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) lifetime distribution width. " 03/01/1998 - "In the control subjects with and without IDDM there was a significant fall in TMA-DPH anisotropy compared to the subjects with diabetic nephropathy in whom the addition of NEM had no effect (deltaTMA-DPH anisotropy -0.005 (-0.020 - +0.006) vs -0.005 (-0.011 - +0.016) vs +0.002 (-0.010 - +0.008) p < 0.001). " 10/01/1998 - "We evaluated polymorphonuclear membrane (PMN) fluidity in 32 subjects with type 1 diabetes mellitus, 38 subjects with type 2 diabetes mellitus and 38 normal control subjects, by marking intact and unstimulated PMN cells with the fluorescent probe 1-[4-(trimethylamino)phenyl]-6-phenyl-1,3,5-hexatriene (TMA-DPH). " 05/01/1997 - "In 13 subjects with insulin-dependent diabetes mellitus (IDDM), in 24 subjects with non-insulin-dependent diabetes mellitus (NIDDM), in 42 VAD subjects, in 23 VAD subjects with NIDDM, in 15 subjects with CRF and in 12 subjects with EH, we determined the PMN membrane fluidity, obtained marking unstimulated PMN cells with fluorescent probe 1-[4-(trimethylamino)phenyl]-6-phenyl-1,3,5-hexatriene (TMA-DPH), and considering the fluorescence polarization degree, and the PMN cytosolic Ca2+ content, obtained marking unstimulated PMN cells with the fluorescent probe Fura2-AM and considering the ratio between the Fura2-Ca2+ complex and the unchelated Fura 2 fluorescence intensity. "
2.	Ischemic Stroke 04/18/2008 - "Thus, the aim of the present study was to investigate Na+/K+ ATPase activity and platelet membrane fluidity, measured by fluorescent probes TMA-DPH and DPH in patients affected by ischemic stroke and controls in order to identify, if any, chemical-physical and/or functional modifications associated with cerebral ischemic damage. "
3.	Photosensitivity Disorders (Photodermatitis) 08/01/1995 - "A decrease in the order parameter (S) of TMA-DPH were observed on photosensitization of cells. " 08/01/1995 - "A decrease in the rotational relaxation time (phi) as well as the cone angle (theta(c)) and an increase in the order parameter (S) of TMA-DPH were observed on photosensitization of cells. " 11/01/2006 - "In contrast, after a 24 h incubation, phototoxicity shows a stronger but imperfect correlation with total cellular photosensitizer uptake rather than TMA-DPH membrane uptake, suggesting a partial shift in the cellular damage responsible for photosensitization from the plasma membrane to intracellular targets. "
4.	Hypertension (High Blood Pressure) 01/01/1995 - "However, the fluorescence polarization anisotropy of TMA-DPH was increased significantly (reflecting increased membrane microviscosity) in hypertensive patients with a family history of hypertension compared with in patients without a family history of hypertension. " 01/01/1995 - "Patients with a family history of hypertension were clustered, with significantly lower Km for sodium and higher TMA-DPH anisotropies than either hypertensive patients without a family history of hypertension or normotensive controls. " 01/01/1991 - "The fluorescence anisotropy values of TMA-DPH (trimethylamino-diphenylhexatriene, probe selectively incorporated into the outer leaflet of the plasma membrane) was evaluated in platelets and erythrocytes of sodium-dependent hypertension-prone and -resistant rats of the Sabra Strain. "
5.	Diabetic Nephropathies (Diabetic Nephropathy) 04/01/1994 - "This was assessed in 21 control subjects, 32 uncomplicated diabetic patients, 17 patients with diabetic nephropathy and 11 patients with non-diabetic nephropathy by measuring the fluorescence anisotropy of DPH and TMA-DPH to assess different membrane regions. " 03/01/1998 - "In the control subjects with and without IDDM there was a significant fall in TMA-DPH anisotropy compared to the subjects with diabetic nephropathy in whom the addition of NEM had no effect (deltaTMA-DPH anisotropy -0.005 (-0.020 - +0.006) vs -0.005 (-0.011 - +0.016) vs +0.002 (-0.010 - +0.008) p < 0.001). "

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	Adenosine Triphosphatases (ATPase)
3.	Diphenylhexatriene
4.	Lipids
5.	Sodium
6.	Phospholipids (Phosphatides)
7.	Membrane Lipids
8.	Cholesterol
9.	1- (4- (trimethylamino)phenyl)- 6- phenylhexa- 1,3,5- triene
10.	diphenyl (biphenyl)