murabutide

adjuvant devoid of pyrogenicity

Also Known As:

AMAIG-BE; N-AcMu-Ala-Gln-n-butyl ester; N-acetylmuramyl-L-alanyl-D-glutamine-n-butyl ester; N-acetylmuramyl-alanylglutamine-n-butyl ester; N2-(N-(N-acetylmuramoyl)-L-alanyl)-butyl ester D-glutamine; muramyl dipeptide butyl ester

Networked: 19 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Amino Sugars: 110
  - Muramic Acids: 28
    - Acetylmuramyl-Alanyl-Isoglutamine: 467
      - murabutide: 19
- Sugar Acids: 4
  - Muramic Acids: 28
    - Acetylmuramyl-Alanyl-Isoglutamine: 467
      - murabutide: 19
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Glycopeptides: 1928
    - Acetylmuramyl-Alanyl-Isoglutamine: 467
      - murabutide: 19

Experts

1.	Rao, D N: 4 articles (02/2008 - 11/2003)
2.	Bahr, G M: 4 articles (09/2001 - 09/2000)
3.	Chattree, Vineeta: 3 articles (02/2008 - 11/2003)
4.	Khanna, Neena: 3 articles (02/2008 - 11/2003)
5.	Darcissac, E C: 3 articles (09/2001 - 09/2000)
6.	Dewulf, J: 3 articles (08/2001 - 09/2000)
7.	Bisht, Vandana: 2 articles (02/2008 - 10/2007)
8.	Sridevi, K: 2 articles (01/2004 - 11/2003)
9.	Vidal, V: 2 articles (09/2001 - 08/2001)
10.	Capron, A: 2 articles (08/2001 - 09/2000)

Related Diseases

1.	Anthrax 04/01/2014 - "Advax-adjuvanted recombinant protective antigen provides protection against inhalational anthrax that is further enhanced by addition of murabutide adjuvant." 04/01/2014 - "Thus, the combination of Advax and murabutide provided enhanced protection against inhalational anthrax with reduced localized inflammation, making this a promising next-generation anthrax vaccine adjuvanting strategy. " 04/01/2014 - "This study sought to determine in a murine model of pulmonary anthrax infection whether the polysaccharide adjuvant Advax or the innate immune adjuvant murabutide alone or together could enhance PA immunogenicity by comparison to an alum adjuvant. "
2.	Neoplasms (Cancer) 04/01/1996 - "In addition, the combination of murabutide with type I IFN exhibited synergistic antitumor activity that was clearly seen in the significant regression of MethA tumors and resulted in almost 50 percent tumor-free mice. " 02/01/1996 - "These preclinical findings will be pursued by the evaluation of the clinical tolerance and biologic activity of the murabutide/IL-2 combination therapy in cancer patients." 02/01/1996 - "Furthermore, the combined administration of murabutide with IL-2 into Meth-A sarcoma-bearing mice resulted in a very significant tumor inhibition as well as in complete tumor regression in nearly 70% of the treated mice. " 04/01/1996 - "At the same time, we have evaluated the efficacy of the synthetic immunomodulator murabutide when administered alone or in combination with type I IFN to protect against ConA hepatitis and in the treatment of tumors in MethA sarcoma-bearing mice. " 01/01/2013 - "In addition to its well recognized adjuvant effect, murabutide has also been shown to enhance the host's resistance against microbial infections, nonspecific resistance against tumors and the induction of cytokines and chemokines implicated in enhancing the immune response and hematopoesis. "
3.	Sarcoma (Soft Tissue Sarcoma) 02/01/1996 - "Furthermore, the combined administration of murabutide with IL-2 into Meth-A sarcoma-bearing mice resulted in a very significant tumor inhibition as well as in complete tumor regression in nearly 70% of the treated mice. " 04/01/1996 - "At the same time, we have evaluated the efficacy of the synthetic immunomodulator murabutide when administered alone or in combination with type I IFN to protect against ConA hepatitis and in the treatment of tumors in MethA sarcoma-bearing mice. "
4.	Inflammation (Inflammations) 04/01/1996 - "Our results demonstrate a prophylactic effect as well therapeutic effects of type I IFN and of murabutide in the inflammation-mediated model of liver damage. " 04/01/2014 - "Thus, the combination of Advax and murabutide provided enhanced protection against inhalational anthrax with reduced localized inflammation, making this a promising next-generation anthrax vaccine adjuvanting strategy. " 04/01/2014 - "In addition, the combination of Advax plus murabutide induced approximately 3-fold-less inflammation than Alhydrogel as measured by in vivo imaging of cathepsin cleavage resulting from injection of ProSense 750. "
5.	Hepatitis 04/01/1996 - "At the same time, we have evaluated the efficacy of the synthetic immunomodulator murabutide when administered alone or in combination with type I IFN to protect against ConA hepatitis and in the treatment of tumors in MethA sarcoma-bearing mice. "

Related Drugs and Biologics

1.	Antigens
2.	Immunologic Factors (Immunomodulators)
3.	delta inulin
4.	Anthrax Vaccines (Vaccines, Anthrax)
5.	Cytokines
6.	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)
7.	Peptide T
8.	Proteins (Proteins, Gene)
9.	Polysaccharides (Glycans)
10.	Phytohemagglutinins

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy