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des-enkephalin-gamma-endorphin
Also Known As:
DEGAMMAE; Org 5878; Org-5878; beta-LPH(66-77); beta-endorphin(6-17); beta-lipotropin 66-77; alpha-Endorphin, 1-de-L-tyrosine-2-deglycine-3-deglycine-4-de-L-phenylalanine-5-de-L-methionine-16a-L-leucine-
Networked:
5
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Opioid Peptides: 1339
Endorphins: 977
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Peptides: 82426
Neuropeptides: 6772
Opioid Peptides: 1339
Endorphins: 977
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
beta-Endorphin: 1766
des-enkephalin-gamma-endorphin: 5
Experts
1.
Capasso, Anna
: 2 articles (03/2009 - 02/2002)
2.
Loizzo, Alberto
: 1 article (02/2002)
Related Diseases
1.
Schizophrenia (Dementia Praecox)
07/01/1990 - "
Des-enkephalin-gamma-endorphin in the treatment of schizophrenia.
"
08/01/1992 - "
Inadequate treatment response to des-enkephalin-gamma-endorphin compared with thioridazine and placebo in schizophrenia.
"
07/01/1990 - "
Ninety-three patients with an exacerbation of chronic schizophrenia were included in a 4 week trial comparing placebo with 1, 3 and 10 mg des-enkephalin-gamma-endorphin (DE gamma E; beta-lipotrophin 66-77; Org 5878) per day (i.m.).
"
08/01/1992 - "
In the multicentre study reported here, 96 patients suffering from schizophrenia (DSM-III with a current exacerbation if chronic) were allocated randomly to double-blind treatment with either des-enkephalin-gamma-endorphin (DE-gamma-E) (Org 5878) 10 mg given as a once daily intramuscular injection for 4 weeks, thioridazine 400 mg orally in 2 divided doses or placebo using a double-dummy technique to preserve blindness.
"
2.
Blindness (Hysterical Blindness)
08/01/1992 - "
In the multicentre study reported here, 96 patients suffering from schizophrenia (DSM-III with a current exacerbation if chronic) were allocated randomly to double-blind treatment with either des-enkephalin-gamma-endorphin (DE-gamma-E) (Org 5878) 10 mg given as a once daily intramuscular injection for 4 weeks, thioridazine 400 mg orally in 2 divided doses or placebo using a double-dummy technique to preserve blindness.
"
3.
Contracture
02/01/2002 - "
DTgammaE or DEgammaE injection treatment before or after morphine, DAGO, U50-488H, beta-endorphin or deltorphin were able to both prevent and reverse the naloxone-induced contracture after exposure to the opioid agonists in a concentration-dependent fashion.
"
03/01/2009 - "
DTgammaE or DEgammaE injection before or after treatment with morphine, DAGO, U50-488H, beta-endorphin or deltorphin was able of both preventing and reversing the naloxone-induced contracture after exposure to the opioid agonists in a concentration-dependent fashion.
"
4.
Seizures (Absence Seizure)
09/01/1990 - "
The beta-endorphin cleavage derivatives des-tyr-gamma-endorphin (DT gamma E) and des-enkephalin-gamma-endorphin (DE gamma E), when injected i.v. for 4 days prevented the EEG ictal seizures induced by CRF in the hippocampus of rabbits and partly prevented the tardive enhancement of theta wave amplitude and frequency.
"
5.
Opioid-Related Disorders (Opiate Addiction)
02/01/2002 - "
Our results indicate that both DTgammaE or DEgammaE are able to reduce significantly opioid dependence in vitro, suggesting an important functional interaction between beta-endorphin fragments and opioid dependence induced by mu, kappa and delta receptors.
"
02/01/2002 - "
The effect exerted by two beta-endorphin fragments (DTgammaE and DEgammaE) was investigated on the acute opioid dependence induced by mu, kappa and delta receptor agonists in vitro.
"
Related Drugs and Biologics
1.
des-enkephalin-gamma-endorphin
2.
Thioridazine (Mellaril)
3.
beta-Lipotropin (Lipotropin)
4.
beta-Endorphin (Endorphin, beta)
5.
Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
6.
Naloxone (Narcan)
7.
Morphine (MS Contin)
8.
Opioid Analgesics (Opioids)
9.
deltorphin
10.
des-Tyr(1)- gamma-endorphin
Related Therapies and Procedures
1.
Intramuscular Injections
2.
Aftercare (After-Treatment)