polyhistidine

RN refers to (L)-isomer; polyhistidine fusion tag, usually consisting of six consecutive histidines added to the end of a protein, allows easy purification with metal-chelate resins;

Also Known As:

Networked: 62 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Dawei: 8 articles (01/2020 - 05/2014)
2.	Qiao, Mingxi: 8 articles (01/2020 - 05/2014)
3.	Zhao, Xiuli: 7 articles (01/2020 - 12/2014)
4.	Hu, Haiyang: 6 articles (01/2020 - 12/2014)
5.	Li, Zhen: 5 articles (01/2018 - 05/2014)
6.	Bae, You Han: 5 articles (11/2013 - 09/2007)
7.	Jeong, Young-Il: 4 articles (05/2018 - 01/2012)
8.	Qiu, Lipeng: 4 articles (01/2016 - 05/2014)
9.	Kang, Dae Hwan: 4 articles (05/2014 - 01/2012)
10.	Chen, Qing: 3 articles (01/2016 - 12/2014)

Related Diseases

1.	Neoplasms (Cancer) 04/15/1997 - "Its remarkable stability at 37 degrees in serum, the ease of production, and purification by affinity chromatography via polyhistidine tail make this smaller version of a bispecific Ab a promising candidate for a therapeutic trial in patients with solid tumor. " 04/01/2022 - "Keeping in mind that the pH of the tumor intercellular medium is ∼5.5, in this paper, we examined the functionalization of a convenient drug delivery vehicle with cell-penetrating poly(l-histidine) to provide a smart drug delivery system. " 01/01/2018 - "A proven anti-tumor immune regulator, R848, was encapsulated with poly(L-histidine) (PHIS) to form PHIS/R848 nanocores. " 05/01/2014 - "Lipo-poly(L-histidine) hybrid materials with pH-sensitivity, intracellular delivery efficiency, and intrinsic targetability to cancer cells." 10/10/2014 - "These results suggest the potential use of polyhistidine for cancer immunotherapy."
2.	Malaria 10/15/2014 - "The aim of the present study was to evaluate the performance characteristics of a one-step Urine Malaria Test™ (UMT) dipstick in detecting Plasmodium falciparum HRP2, a poly-histidine antigen in urine of febrile patients for malaria diagnosis. " 01/31/2012 - "Proof-of-principle studies using poly-L-histidine, a peptide mimic of the malaria biomarker pfHRPII, show that the predicted particle distributions occur with a limit of detection of approximately 200-300 nM."
3.	Carcinoma (Carcinomatosis) 01/01/2019 - "In this study, we demonstrate a modified L6 (HL6; CHHHHHRRWQWRHHHHHC), in which short polyhistidine peptides are introduced into both flanks of L6, has enhanced cell-penetrating ability in human bronchoalveolar carcinoma A549 cells. " 08/01/2006 - "To examine the function of TAA90K in colon cancer, we carried out protein and cell binding assays using TAA90K-His purified from HT-29 cells colon carcinoma cells infected with recombinant vaccinia virus expressing TAA90K containing a C-terminal poly-histidine tag. " 05/13/2013 - "Dual stimuli-responsive poly(N-isopropylacrylamide)-b-poly(L-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma." 05/05/1997 - "Serine phosphorylation of human pro-urokinase (pro-uPA) by A431 human carcinoma cells results in a catalytically active molecule with reduced sensitivity to plasminogen activator inhibitor type 1. We mapped the phosphorylated seryl residues by analyzing the in vivo phosphorylation state of engineered pro-uPA variants carrying a COOH-terminal poly-histidine tag. " 12/15/1999 - "To investigate whether expression of an angiogenesis inhibitor by cancer cells could alter this balance and prevent tumor formation in different organ environments, we engineered stable transfectants from RenCa mouse renal carcinoma cells and SW620 human colon carcinoma cells to constitutively secrete a mouse endostatin protein with c-myc and polyhistidine (His) tags. "
4.	Breast Neoplasms (Breast Cancer) 08/02/2019 - "Multi-Modulation of Doxorubicin Resistance in Breast Cancer Cells by Poly(l-histidine)-Based Multifunctional Micelles." 05/14/2018 - "The aim of this study is to synthesize multifunctional hybrid nanoparticles composed of hyaluronic acid (HA) and poly(l-histidine) (PHS) with a disulfide linkage and chlorin e6 (HAPHSce6ss) for diagnostic and therapeutic application against breast tumor cells. " 01/01/2018 - "A multifunctional nanoparticulate system composed of methoxy poly(ethylene glycol)-poly(l-histidine)-d-α-vitamin E succinate (MPEG-PLH-VES) copolymers for encapsulation of doxorubicin (DOX) was elaborated with the aim of circumventing the multidrug resistance (MDR) in breast cancer treatment. " 12/01/2014 - "To address this issue, a new pH-sensitive mixed copolymer micelles system composed of hyaluronic acid-g-poly(l-histidine) (HA-PHis) and d-α-tocopheryl polyethylene glycol 2000 (TPGS2k) copolymers was developed to co-deliver doxorubicin (DOX) and TPGS2k into drug-resistant breast cancer MCF-7 cells (MCF-7/ADR). "
5.	Neuroblastoma 11/04/2005 - "To determine the biological implications of the different polyhistidine repeat lengths, we expressed these variants in COS-7 and a human neuroblastoma cell line (SK-N-SH). " 07/01/2014 - "In this study immunocytochemical staining of human SH-SY5Y neuroblastoma cell lines with the HIS-1 anti-polyhistidine monoclonal antibody were determined. " 07/01/2014 - "These results suggest that anti-polyhistidine antibody staining shows significant cross-reactivity with endogenous nuclear proteins in SH-SY5Y neuroblastoma cells and may not be suitable for localization studies of histidine-tagged proteins. "

Related Drugs and Biologics

1.	Micelles
2.	Peptides (Polypeptides)
3.	Hyaluronic Acid (Hyaluronan)
4.	peptide A
5.	Ligands
6.	polyethylene glycol 2000
7.	human ERBB2 protein
8.	Proteins (Proteins, Gene)
9.	poly(lactide) (polylactic acid)
10.	Ethylene Glycol (Monoethylene Glycol)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Precision Medicine
4.	Injections
5.	Immunotherapy