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galaxolide

musk fragrance; structure given in first source

Also Known As:

1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran; HHCB cpd; hexahydro-hexamethylcyclopenta-benzopyran

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - galaxolide: 8
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - galaxolide: 8

Experts

1.	Kamarck, Marissa L: 1 article (01/2022)
2.	Keller, Andreas: 1 article (01/2022)
3.	Li, Bingjie: 1 article (01/2022)
4.	Lim, Fei-Ling: 1 article (01/2022)
5.	Mainland, Joel D: 1 article (01/2022)
6.	Peng, Qianqian: 1 article (01/2022)
7.	Smeets, Monique A M: 1 article (01/2022)
8.	Wang, Sijia: 1 article (01/2022)
9.	Chasan, Tourkian: 1 article (12/2021)
10.	Doğanlar, Oğuzhan: 1 article (12/2021)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2021 - "Prolonged sub-lethal exposure to galaxolide (HHCB) and tonalide (AHTN) promotes the metastatic potential of glioblastoma tumor spheroids." 04/01/2014 - "Galaxolide and Tonalide also induced human cancer cell degeneration with EC50 values of 26 and 98 μM (neuroblastoma SH-SY5Y cells) and 58 and 14 μM (lung cancer A549 cells), respectively. " 10/01/2003 - "During this study a number of PPCPs including painkillers (aspirin, ibuprofen), cholesterol control medication (clofibric acid), antibacterial agents (triclosan), musks (including galaxolide and tonalide), X-ray contrast media (diatrizoate), cancer treatment drugs (cyclophosphamide) and anti-depressant drugs (fluvoxamine) were investigated. "
2.	Body Weight (Weight, Body) 03/01/2013 - "This study investigates the metabolism and mode of action of galaxolide (HHCB) in the European sea bass -Dicentrarchus labrax- following a single intraperitoneal injection of 50 mg HHCB/kg body weight. "
3.	Neuroblastoma 04/01/2014 - "Galaxolide and Tonalide also induced human cancer cell degeneration with EC50 values of 26 and 98 μM (neuroblastoma SH-SY5Y cells) and 58 and 14 μM (lung cancer A549 cells), respectively. "
4.	Lung Neoplasms (Lung Cancer) 04/01/2014 - "Galaxolide and Tonalide also induced human cancer cell degeneration with EC50 values of 26 and 98 μM (neuroblastoma SH-SY5Y cells) and 58 and 14 μM (lung cancer A549 cells), respectively. "
5.	Hepatocellular Carcinoma (Hepatoma) 12/12/1997 - "Galaxolide, tonalide, celestolide, phantolide, cashmeran and traseolide revealed no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2." 12/12/1997 - "The synthetic polycyclic musk fragrance compounds galaxolide (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-b enzopyrane), tonalide (7-acetyl-1,1,3,4,4,6-hexamerthyltetraline), celestolide (4-acetyl-1,1-dimethyl-6-tert-butylindane), phantolide (6-acetyl-1,1,2,3,3,5-hexamethylindane), cashmeran (6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H) indanone) and traseolide (5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane) were examined for their genotoxicity in the micronucleus test (MNT) with human lymphocytes in vitro in the presence and absence of an exogenous metabolizing system containing rat liver S9 and the metabolically competent human hepatoma cell line Hep G2. "

Related Drugs and Biologics

1.	acetyl methyl tetramethyl tetralin
2.	Fluvoxamine (Luvox)
3.	Triclosan (pHisoHex)
4.	Ibuprofen (Motrin)
5.	Diatrizoate (Hypaque)
6.	Cyclophosphamide (Cytoxan)
7.	Contrast Media
8.	Clofibric Acid
9.	Cholesterol
10.	Aspirin (Acetylsalicylic Acid)

Related Therapies and Procedures

1.	Intraperitoneal Injections