methyl salicylate (Linsal)

used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990

Also Known As:

Networked: 91 relevant articles (5 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Zhang, Dongming: 2 articles (03/2015 - 07/2014)
2.	Du, Guanhua: 2 articles (03/2015 - 07/2014)
3.	Zhang, Dan: 2 articles (03/2015 - 07/2014)
4.	Zhang, Xue: 2 articles (03/2015 - 07/2014)
5.	Li, Yongjie: 2 articles (03/2015 - 07/2014)
6.	Xin, Wenyu: 2 articles (03/2015 - 07/2014)
7.	Ma, Xiaowei: 2 articles (03/2015 - 07/2014)
8.	Zhang, Tiantai: 2 articles (03/2015 - 07/2014)
9.	Klessig, Daniel F: 2 articles (12/2011 - 10/2007)
10.	Corti, Daniele: 1 article (10/2015)

Related Diseases

1.	Pain (Aches) 03/01/2015 - "Methyl salicylate 2-O-β-D-lactoside (MSL) is a derivative of natural salicylate isolated from Gaultheria yunnanensis (Franch.) Rehder, which is widely used for treating rheumatoid arthritis (RA), swelling and pain. " 01/01/2010 - "A single, 8-hour application of a patch containing methyl salicylate and l-menthol provided significant relief of pain associated with mild to moderate muscle strain in these adult patients compared with patients receiving a placebo patch." 01/01/2010 - "An occlusive patch formulation containing 10% methyl salicylate and 3% l-menthol was recently approved by the US Food and Drug Administration for the treatment of mild to moderate pain. " 01/01/2013 - "This study was designed to compare the efficacy of double-modality therapy, phonophoresis and cryotherapy in the management of pain among subjects who suffered from musculoskeletal injuries (MSIs).Sixty (60) subjects were assigned randomly to one of three groups: DMT group (n=20) received cryotherapy and 15% methyl salicylate phonophoresis, PHONO group (n=20) received 15% methyl salicylate phonophoresis and CRYO group (n=20) received cryotherapy and "sham‟ phonophoresis. " 01/01/2010 - "Despite widespread use of counterirritants, including methyl salicylate and menthol, for topical pain relief, published efficacy and safety data regarding the use of the agents alone or in combination are limited. "
2.	Wounds and Injuries (Trauma) 01/01/2013 - "This study was designed to compare the efficacy of double-modality therapy, phonophoresis and cryotherapy in the management of pain among subjects who suffered from musculoskeletal injuries (MSIs).Sixty (60) subjects were assigned randomly to one of three groups: DMT group (n=20) received cryotherapy and 15% methyl salicylate phonophoresis, PHONO group (n=20) received 15% methyl salicylate phonophoresis and CRYO group (n=20) received cryotherapy and "sham‟ phonophoresis. " 01/01/1996 - "We examined the effects of inhibitors of the octadecanoid pathway (n-propyl gallate, acetosalicylic acid, salicylhydroxamic acid, methyl salicylate, and antipyrine) on wound- and jasmonate-induced nicotine accumulation and compared the nicotine-inducing ability of exogeneous additions of linolenic acid (18:3) and its methyl ester, linoleic acid (18:2), abscisic acid, traumatic acid, and methyl dihydrojasmonate to the nicotine-inducing ability of exogenous additions of methyl jasmonate (MJ). "
3.	Poisoning 06/01/2015 - "Accidental methyl salicylate poisoning in two adults." 01/01/2007 - "A comprehensive review of the existing medical literature on methyl salicylate poisoning was performed, and data compiled over the past two decades by the American Association of Poison Control Centers (AAPCC) was examined. " 09/01/1996 - "Ingestion of methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning because of its liquid, concentrated form and lipid solubility. " 02/01/1996 - "Because of its liquid, concentrated form and lipid solubility, methyl salicylate poses the threat of severe, rapid-onset salicylate poisoning. " 08/18/1968 - "[On certain enzymatic changes in a case of methyl-salicylate acute poisoning]."
4.	Keratosis 06/01/1992 - "A methyl salicylate-buffered, croton oil-containing 50% salicylic acid ointment peel, following pretreatment with topical tretinoin and localized 20% trichloroacetic acid, is extremely effective for removal of lentigines, pigmented keratoses, and actinically damaged skin from the dorsum of the hands and forearms. "
5.	Fibrosis (Cirrhosis) 11/01/1983 - "Morphologic alterations in the gastric microcirculation in cirrhosis were investigated following infusion of a silicone rubber compound into vessels of the excised stomach which was then cleared with methyl salicylate. "

Related Drugs and Biologics

1.	Volatile Oils (Essential Oils)
2.	Oils
3.	Salicylic Acid (2 Hydroxybenzoic Acid)
4.	Thymol
5.	Silicone Elastomers (SE 30)
6.	Trichloroacetic Acid
7.	Tretinoin (Retinoic Acid)
8.	Croton Oil
9.	Methanol (Carbinol)
10.	Listerine

Related Therapies and Procedures

1.	Cryotherapy (Therapy, Cold)
2.	Phonophoresis
3.	Surgical Portasystemic Shunt (Portosystemic Shunt)
4.	Peritoneal Dialysis
5.	Topical Administration