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N'-nitrosoanatabine

nitroso cpd prepared from alkaloid anatabine; structure given in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - N'-nitrosoanatabine: 3

Experts

1.	Richter, Elmar: 1 article (11/2005)
2.	Thalheim, Charlotte: 1 article (11/2005)
3.	Tyroller, Stefan: 1 article (11/2005)
4.	Zwickenpflug, Wolfgang: 1 article (11/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1984 - "Of these, N-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N'-nitrosoanatabine (NAT) were bioassayed at three dose levels by subcutaneous injections into male and female F344 rats in 60 subdoses amounting in total to 9,3, and 1 mmol/kg. Compared with the solvent control group (trioctanoin), both NNN and NNK induced significant numbers of tumors of the nasal cavity (P less than 0.01) at all three dose levels in both male and female rats. "
2.	Leukoplakia 01/21/1992 - "Among reverse-cigar smokers, a high incidence of leukokeratosis nicotina palati, an elevated frequency of micronucleated cells in the palate (2.5% as compared to 0.6% in non-smokers and non-chewers of tobacco) and tongue (2.1%) from which carcinomas preferentially develop, and up to 5890 ppb nitrosonornicotine and up to 1880 ppb N-nitrosoanatabine in the saliva were found. "
3.	Carcinoma (Carcinomatosis) 01/21/1992 - "Among reverse-cigar smokers, a high incidence of leukokeratosis nicotina palati, an elevated frequency of micronucleated cells in the palate (2.5% as compared to 0.6% in non-smokers and non-chewers of tobacco) and tongue (2.1%) from which carcinomas preferentially develop, and up to 5890 ppb nitrosonornicotine and up to 1880 ppb N-nitrosoanatabine in the saliva were found. "
4.	Body Weight (Weight, Body) 11/15/2005 - "with 30nmol/kg body weight (bw) [5-(3)H]NNN either alone or simultaneously with 15mumol/kg bw nicotine, nornicotine, anatabine, or anabasine, 150mumol/kg bw cotinine, 3mumol/kg bw myosmine, or 300nmol/kg bw of either N'-nitrosoanatabine or N'-nitrosoanabasine. "

Related Drugs and Biologics

1.	N'-nitrosonornicotine (nitrosonornicotine)
2.	Solvents
3.	Nicotine
4.	Cotinine
5.	Anabasine
6.	N-acetyltalosaminuronic acid (NAT)
7.	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanone
8.	anatabine
9.	N'-nitrosoanabasine
10.	nornicotine

Related Therapies and Procedures

1.	Subcutaneous Injections