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artemether

quinghaosu derivative

Also Known As:

O-methyldihydroartemisinine; artemether, (3R-(3alpha,5abeta,6alpha,8abeta,9alpha,10beta,12beta,12aR*))-isomer; artemether, (3R-(3alpha,5abeta,6beta,8aalpha,9alpha,10beta,12beta,12aR*))-isomer; artemether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer; artenam; beta-arthemeter; (3R-(3.alpha.,5a.beta.,6.beta.,8a.beta.,9.alpha.,10.alpha.,12.beta.,12aR*))-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4.3-j)-1,2-benzodioxepin

Networked: 752 relevant articles (179 outcomes, 202 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58

Experts

1.	Dorsey, Grant: 27 articles (01/2015 - 05/2006)
2.	White, Nicholas J: 23 articles (10/2015 - 12/2003)
3.	Rosenthal, Philip J: 23 articles (01/2015 - 05/2006)
4.	Kamya, Moses R: 20 articles (01/2015 - 05/2006)
5.	Mårtensson, Andreas: 15 articles (10/2014 - 10/2005)
6.	Utzinger, Jürg: 15 articles (09/2011 - 01/2002)
7.	Davis, Timothy M E: 13 articles (08/2015 - 03/2006)
8.	Björkman, Anders: 13 articles (10/2014 - 10/2005)
9.	Ogutu, Bernhards: 12 articles (08/2015 - 01/2008)
10.	Sowunmi, Akintunde: 12 articles (01/2015 - 08/2007)

Related Diseases

1.	Malaria 01/01/2006 - "Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. " 10/01/2008 - "Solid microemulsion preconcentrate (NanOsorb) of artemether for effective treatment of malaria." 10/01/1999 - "Artemether is a new and effective treatment for malaria, although relapse is a problem in monotherapy. " 11/01/1996 - "artemether would be an effective treatment of severe malaria in the rural tropics in situations where oral or parenteral administration is not possible." 01/01/2014 - "Randomized controlled trials (RCTs) comparing intramuscular artemether with intravenous or intramuscular antimalarial for treating severe malaria. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 11/21/1992 - "Artemether is effective against falciparum malaria but associated with a high recrudescence rate. " 07/01/1997 - "These results suggest that artemether is rapidly effective in acute recrudescent Plasmodium falciparum malaria and is without deleterious side effects." 11/01/2015 - "Efficacy of a Novel Sublingual Spray Formulation of Artemether in African Children with Plasmodium falciparum Malaria." 09/01/1999 - "An open study to evaluate the efficacy of artemether in severe falciparum malaria." 01/01/2008 - "[Efficacy of artemether in the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6-60 months of age in Bangui (Central African Republic)]."
3.	Infection 11/01/2005 - "A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China." 01/01/2003 - "These findings have been confirmed in clinical trials for the former two parasites; administered orally once every 2-3 weeks, artemether significantly reduced the incidence and intensity of patent infections. " 01/01/2003 - "Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections." 05/01/2002 - "Randomized controlled clinical trials confirmed that artemether, orally administered at a dose of 6 mg/kg once every 2-3 weeks, results in no drug-related adverse effects, and significantly reduces the incidence and intensity of schistosome infections. " 01/01/2002 - "Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. "
4.	Cerebral Malaria 03/01/1996 - "The clinical efficacy of intramuscular artemether was studied in 144 children suffering from severe non cerebral malaria. " 05/01/1997 - "The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study." 02/12/2005 - "Rectal artemether is effective and well tolerated and could be used as treatment for cerebral malaria." 10/15/1999 - "Artemether represents an important option in the management of cerebral malaria in Nigeria especially in rural areas where facilities for intravenous administration may not yet be optimal." 05/01/1997 - "The disposition of intramuscular artemether (AM) was studied in 26 Kenyan children with cerebral malaria. "
5.	Parasitemia 10/15/2012 - "In addition, despite adversely affecting parasitemia and weight in non-artemether treated infected mice, HJP-272, seemed to confer some survival benefit when used as adjunctive therapy, though this did not reach significance. " 12/01/1993 - "The effects of artemether on the morphology of Plasmodium falciparum were studied in an owl monkey (Aotus trivirgatus) when parasitemia reached 33% and the animal became severely ill. " 05/06/2004 - "CF(3) analogues of artemether and arteether exhibited a high in vivo antimalarial activity on mice infected with Plasmodium berghei NK173, with a complete clearance of the parasitemia during the entire observation period (25 days)." 08/01/2007 - "Artemether-lumefantrine clears parasitemia more rapidly than ASP but both combinations are effective in treatment of uncomplicated P. " 01/01/1999 - "Findings showed that artemether was more effective than quinine with regard to total clearance of parasitemia, 90 p. "

Related Drugs and Biologics

1.	lumefantrine
2.	artesunate
3.	artemisinine (artemisinin)
4.	Amodiaquine (Camoquin)
5.	Quinine (Quinson)
6.	sulfadoxine-pyrimethamine (Fansidar)
7.	Mefloquine (Lariam)
8.	piperaquine
9.	dihydroquinghaosu (dihydroartemisinin)
10.	Chloroquine (Aralen)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Intravenous Infusions
5.	Therapeutics