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lysophosphatidic acid (MOPA)

Subscribe to New Research on lysophosphatidic acid

RN given refers to parent cpd

Also Known As:

MOPA; 1-O-oleyllysophosphatidic acid; 1-oleoyl-lysophosphatidic acid; LPA (lysophosphatidic acid); monooleylphosphatidate; monooleylphosphatidic acid; monooleylphosphatidic acid, (R)-isomer; monooleylphosphatidic acid, sodium salt, (R)-isomer; 1-acyl-sn-glycerol-3-phosphate

Networked: 715 relevant articles (7 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 18571
- Membrane Lipids: 413
  - Phospholipids: 4030
    - Glycerophosphates: 11
      - Phosphatidic Acids: 240
        Lysophospholipids: 212
        lysophosphatidic acid: 715

Experts

1.	Chun, Jerold: 27 articles (02/2014 - 06/2002)
2.	Aoki, Junken: 25 articles (02/2015 - 07/2002)
3.	Fukushima, Nobuyuki: 18 articles (08/2014 - 06/2002)
4.	Ueda, Hiroshi: 18 articles (01/2014 - 01/2006)
5.	Mills, Gordon B: 18 articles (02/2013 - 05/2002)
6.	Tsujiuchi, Toshifumi: 16 articles (08/2014 - 05/2008)
7.	Xu, Yan: 15 articles (09/2015 - 09/2002)
8.	Morris, Andrew J: 14 articles (03/2014 - 03/2003)
9.	Arai, Hiroyuki: 14 articles (02/2008 - 07/2002)
10.	Fang, Xianjun: 13 articles (09/2015 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2009 - "To observe the effect of lysophosphatidic acid on cervical cancer cell line HeLa cells proliferation, adhesion, migration and apoptosis and study related signaling pathway. " 06/20/2014 - "Inactivation of INPP1 leads to a reduction in glycolytic intermediates that feed into the synthesis of the oncogenic signaling lipid lysophosphatidic acid (LPA), which in turn impairs LPA signaling and further attenuates glycolytic metabolism in a feed-forward mechanism to impair cancer cell motility, invasiveness, and tumorigenicity. " 01/01/2014 - "Lysophosphatidic acid (LPA) is involved in a number of biological processes, and may have a role in cancer cell migration and invasiveness. " 11/01/2013 - "Lysophosphatidic acid (LPA) is a lysophospholipid that mediates multiple behaviors in cancer cells, such as proliferation, migration and adhesion. " 10/01/2013 - "Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression."
2.	Fibrosis (Cirrhosis) 01/01/2014 - "Recent studies indicate that lysophosphatidic acid (LPA) is also significantly involved in wound healing and the development of fibrosis. " 12/01/2010 - "This study was designed to determine: (i) whether fibroblasts isolated from skin of patients with SSc have increased lysophosphatidic acid-activated Cl- current (IClLPA) activity vs healthy controls; (ii) whether myofibroblast differentiation is involved in SSc skin fibrosis; and (iii) whether SSc fibroblasts have different proliferation rates vs controls. " 09/01/2014 - "Lysophosphatidic acid (LPA) and LPA1/3 plays a role in lung fibrosis. " 01/01/2014 - "Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts." 10/01/2013 - "Development of lysophosphatidic acid pathway modulators as therapies for fibrosis."
3.	Glioma (Gliomas) 12/01/2009 - "In this study, we have focused on the negative regulation of lysophosphatidic acid (LPA)-induced migration in glioma cells. " 05/01/2005 - "We studied pathways involved in the proliferation of rat C6 glioma cells induced by lysophosphatidic acid (LPA), a phospholipid with diverse biological functions. " 05/01/2005 - "Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid." 03/01/2000 - "Role of lysophosphatidic acid and rho in glioma cell motility." 01/01/1997 - "Lysophosphatidic acid depletes intracellular calcium stores different from those mediating capacitative calcium entry in C6 rat glioma cells."
4.	Carcinoma (Carcinomatosis) 01/01/2002 - "Several studies have shown that lysophosphatidic acid (LPA), a phospholipidic chemical mediator, is relevant to the pathogenesis of ovarian carcinoma. " 09/04/2015 - "Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma." 01/01/2009 - "Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis." 05/21/2003 - "Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells." 04/01/2003 - "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1."
5.	Lung Injury 12/01/2015 - "In this present study, we hypothesize that lysophosphatidic acid (LPA) mediates NKT cell activation in a mouse model of hyperoxic lung injury. " 09/04/2009 - "Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury." 12/01/2015 - "Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury." 03/01/2014 - "Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study." 03/01/2012 - "Lysophosphatidic acid (LPA), which we have previously demonstrated to mediate bleomycin lung injury-induced fibroblast recruitment and vascular leak in mice and fibroblast recruitment in patients with IPF, is an important regulator of survival and apoptosis in many cell types. "

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6.	Bleomycin (Blenoxane)
7.	Histidine (L-Histidine)
8.	Glucose (Dextrose)
9.	Lecithins
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Ligation
2.	Intravenous Injections
3.	Heterologous Transplantation (Xenotransplantation)
4.	Aftercare (After-Treatment)
5.	Immunomodulation