1-nitropyrene

04/01/1990 - "A small, but significant, increase in tumor incidence, with a dose-response trend, was observed only in Study 2 hamsters receiving 1-nitropyrene once weekly. "
08/01/1988 - "The induction of mammary tumors by 1-nitropyrene confirms the results of a previous study (Hirose et al., Cancer Res., 44: 1158-1162, 1984). "
08/01/1988 - "Low and generally insignificant incidences of tumors of a variety of other sites were also observed in rats treated with 1-nitropyrene. "
05/01/1984 - "Tumor initiating activities of 1-nitropyrene and its nitrated products in SENCAR mice."
07/01/1988 - "This study was carried out in order to evaluate possible mechanisms responsible for tumor induction by 1-nitropyrene and to provide insights on the higher tumorigenicity of 1-nitrosopyrene than 1-nitropyrene in newborn mouse liver. "

10/01/1994 - "Pathways for the mutagenesis of 1-nitropyrene and dinitropyrenes in the human hepatoma cell line HepG2."
01/01/2003 - "The hepatocellular carcinomas were induced by the administration of bleomycin and 1-nitropyrene were evaluated for point mutations in exon 1 and exon 2 of the K-ras gene by the polymerase chain reaction and a sequencing analysis. "
01/01/1991 - "Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2."
06/15/1987 - "Mutagenicity, unscheduled DNA synthesis, and metabolism of 1-nitropyrene in the human hepatoma cell line HepG2."
01/01/2003 - "In the present study, hepatocellular carcinomas were induced in male A/J mice by the intraperitoneal injection of bleomycin (120 mg/kg) followed by the intraperitoneal administration of 1-nitropyrene (total dose: 1,575 mg/kg). "

10/01/1984 - "The results of this study indicate that metabolic reduction of the highly mutagenic 1-nitrohydroxypyrenes occurs in vivo in the rat and suggest that this is a possible activation pathway in 1-nitropyrene carcinogenesis."
10/01/1990 - "1-Nitropyrene (99.85-99.98% 1-nitropyrene, 0.15-0.02% 1,3-, 1,6- and 1,8-dinitropyrene by mass spectral analyses) was administered to Sprague-Dawley rats, CD-1 mice and A/J mice according to three tumorigenesis protocols. "
02/01/1985 - "The importance of these pathways in the etiology of 1-nitropyrene tumorigenesis is discussed."
04/01/1990 - "The carcinogenic potential of 1-nitropyrene, a major mutagenic constituent of diesel-exhaust particles, was investigated using a hamster respiratory-carcinogenesis model. "

04/01/1990 - "In both studies, hamsters receiving 1-nitropyrene showed a dose-related decrease in survival and body-weight gain. "
11/01/1989 - "The capability of liver microsomes to catalyze the oxidative metabolism of 1-nitropyrene was unchanged after treating rats with a single dose of 8 mg of 1-nitropyrene per kilogram of body weight. "
02/01/1988 - "The possible carcinogenicities of phenolic metabolites of 1-nitropyrene were examined by subcutaneous treatment of newborn animals, and at seven weekly intervals, with 1-nitropyrene, 3-hydroxy-1-nitropyrene, or a mixture of 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene (70 mumoles/ml; 100 mumoles/kg body weight; total dose, 63 mumoles). "
02/01/1988 - "Subcutaneous and intraperitoneal treatments of weanling female CD rats (70 mumoles/ml; 100 mumoles/kg body weight; 5 weekly injections) with 1-nitropyrene were carried out to explore possible differences because of the different routes of administration in animals of the same age. "
11/01/1998 - "The treatment of 6-8 week-old CBA/Ca mice with a single 30 mumol/kg body weight dose of 1-nitropyrene caused a significant increase in chromosome aberrations 48 hours after exposure. "

05/01/2013 - "Pyrene, one of the most widely studied PAHs, along with its mono-substituted derivatives, 1-amino, 1-bromo, 1-hydroxy, and 1-nitropyrene, were chosen to study the effect of substituents on their phototoxicity, DNA damage and repair. "