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tin protoporphyrin IX

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competitive inhibitor of heme oxidation

Also Known As:

Sn protoporphyrin; SnPP IX; SnPP protoporphyrin; tin-protoporphyrin; Stannate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-

Networked: 140 relevant articles (13 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Leffler, Charles W: 4 articles (06/2012 - 09/2003)
2.	Parfenova, Helena: 4 articles (06/2012 - 09/2003)
3.	Ferrándiz, Maria Luisa: 4 articles (05/2012 - 01/2005)
4.	Alcaraz, Maria José: 3 articles (12/2011 - 01/2005)
5.	Tsai, Pei-Shan: 3 articles (06/2011 - 05/2007)
6.	Huang, Chun-Jen: 3 articles (06/2011 - 05/2007)
7.	Amon, Michaela: 3 articles (04/2007 - 02/2003)
8.	Menger, Michael D: 3 articles (04/2007 - 02/2003)
9.	Carratu, Pierluigi: 3 articles (06/2005 - 09/2003)
10.	Braza-Boïls, Aitana: 2 articles (05/2012 - 09/2011)

Related Diseases

1.	Hematoma 02/01/1986 - "The effect of a single prophylactic dose of tin protoporphyrin on the carbon monoxide (CO) excretion rate of antibiotic-treated neonatal rats before and after hematoma formation was evaluated. " 08/01/1985 - "Effect of tin protoporphyrin on the excretion rate of carbon monoxide in newborn rats after hematoma formation." 02/01/1986 - "These studies demonstrate that tin protoporphyrin is an effective in vivo inhibitor of endogenous heme catabolism as measured by the CO excretion rate in antibiotic-treated neonatal rats with and without artificially created hematomas." 02/01/1986 - "The CO excretion rate, reflecting the rate of bilirubin production, of tin protoporphyrin-treated (TP-H) rats 24 hours after injection of 65 mole of tin protoporphyrin per kilogram (time [t] = 0 hours) was approximately 18% lower than those of the saline-control (S-C) and saline-hematoma (S-H) rats, but this difference was no longer evident at t = 43 hours. " 08/01/1985 - "This study evaluated the efficacy of tin protoporphyrin (TP), a competitive inhibitor of heme oxygenase, in suppressing the total body excretion rate of carbon monoxide (CO), an index of total bilirubin formation, in neonatal rats with artificially created hematomas. "
2.	Neonatal Jaundice 06/01/1992 - "However, if it can be shown that tin-protoporphyrin can serve as a safe and less costly alternate treatment, a considerable improvement in the management of neonatal jaundice would be achieved." 01/01/1990 - "However, if it can be shown that the use of tin-protoporphyrin can serve as a safe and less costly alternate treatment, a considerable improvement in the management of neonatal jaundice will be achieved." 09/01/1987 - "Tin-protoporphyrin and neonatal jaundice." 09/24/1982 - "Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model." 02/01/1993 - "The heme oxygenase inhibitor, tin protoporphyrin, is being studied for the prevention of neonatal jaundice. "
3.	Hepatic Porphyrias (Hepatic Porphyria) 12/01/1985 - "Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. " 08/01/1993 - "Tin protoporphyrin prolongs the biochemical remission produced by heme arginate in acute hepatic porphyria." 07/27/1991 - "Haem-arginate plus tin-protoporphyrin for acute hepatic porphyria." 12/01/1985 - "These findings in a rat model of hepatic porphyria suggest that Sn-protoporphyrin may be useful in the treatment of acute exacerbations of "inducible" hepatic porphyrias in man, especially since Sn-protoporphyrin, unlike hematin which is presently used for this purpose, is neither degraded by nor induces the activity of heme oxygenase." 06/01/1989 - "Administration of both tin-protoporphyrin and tin-mesoporphyrin resulted in decreases in the urinary excretion of heme pathway intermediates in stable hyperexcreters with acute hepatic porphyria."
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 06/03/1989 - "Sn-protoporphyrin with conventional UVA light may be useful in the treatment of psoriasis." 01/01/1989 - "As shown in this study, one-day treatment with Sn-protoporphyrin followed by conventional UVA light treatment may be a useful therapeutic modality for psoriasis patients and merits further investigation." 06/03/1989 - "Tin-protoporphyrin and long wave length ultraviolet light in treatment of psoriasis." 06/03/1989 - "To assess the effects of tin (Sn)-protoporphyrin (a synthetic haem analogue) in conjunction with long wave length ultraviolet light (UVA) radiation in psoriasis 10 patients, 9 of whom were substantially or completely unresponsive to other forms of therapy, received 2.0 mumol/kg bodyweight of Sn-protoporphyrin for 1 day followed by UVA light treatment for 21 days. " 11/01/1996 - "We have reviewed the results of clinical investigations into the use of photodynamic therapy (PDT) with intravenous injection of hematoporphyrin derivative (HpD), Photofrin (PF) and Sn-protoporphyrin (Sn-Pp) or oral administration of delta-aminolevulinic acid in the treatment of skin cancers and/or psoriasis. "
5.	Pre-Eclampsia (Preeclampsia) 05/01/2000 - "Hemin-induced vessel relaxation and CO production was inhibited by HO inhibitor, tin protoporphyrin IX. Our findings establish HO-1 as an endogenous system that offers protection against cytotoxic damage in the placenta, identifies the HO-CO pathway to regulate feto-placental circulation and provides a new approach to study the disease of preeclampsia."

Related Drugs and Biologics

1.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
2.	Carbon Monoxide
3.	Heme (Haem)
4.	Hemin (Panhematin)
5.	Bilirubin
6.	glucuronyl glucosamine glycan sulfate (Vessel)
7.	Heme Oxygenase-1
8.	Small Interfering RNA (siRNA)
9.	heme arginate
10.	Ozone

Related Therapies and Procedures

1.	Resuscitation
2.	Phototherapy (Light Therapy)
3.	Oral Administration
4.	Intraventricular Infusions
5.	Transplants (Transplant)