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2- ((5- chloro- 2- methoxyphenyl)azo)- 1H- imidazole
RN given refers to parent cpd; structure in first source
Also Known As:
2-((5-chloro-2-methoxyphenyl)azo)-1H-imidazole hydrochloride; M 6434; M-6434; M6434
Networked:
5
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
2-((5-chloro-2-methoxyphenyl)azo)-1H-imidazole: 5
Related Diseases
1.
Hemorrhagic Shock
01/01/1984 - "
M6434 improved the survival rate of rabbits in hemorrhagic shock.
"
03/01/1989 - "
Mechanisms involved in the effect of M6434 on experimental hemorrhagic shock: II. Effects on energy metabolism and organ blood flow.
"
03/01/1989 - "
Mechanisms involved in the effect of M6434 on experimental hemorrhagic shock: I. Effects on myocardial contractility and venous return.
"
03/01/1989 - "
Dopamine had no effect at 20 micrograms/kg/min, but it increased venous return in both states at 50 micrograms/kg/min. These results suggest that M6434 may improve the hemodynamic derangement in severe hemorrhagic shock through decreasing venous blood pooling.
"
2.
Orthostatic Hypotension (Postural Hypotension)
11/01/1992 - "
These results show that M6434 possesses a potent hypertensive effect with a weaker bradycardiac action and suggest that M6434 may be a potential candidate for an anti-hypotensive agent that can prevent the deterioration of hemodynamics in postural hypotension.
"
11/01/1992 - "
In the postural hypotension of anesthetized dogs, M6434 at the doses more than 10 micrograms/kg, i.v. also produced the preventive effects on mean blood pressure and cerebral tissue blood flow.
"
11/01/1992 - "
We examined the effects of M6434 on mean blood pressure and heart rate in conscious rabbits and dogs and on experimental models of postural hypotension in conscious rabbits and anesthetized dogs.
"
11/01/1992 - "
[Effects of M6434, an orally active alpha 1-adrenoceptor agonist, on experimental postural hypotension in rabbits and dogs].
"
06/01/1992 - "
These results suggest that M6434 possesses a potent antihypotensive activity which is superior to that of midodrine, and M6434 may be useful in the treatment of essential and postural hypotension.
"
3.
Cardiogenic Shock
01/01/1984 - "
Survival rates of cardiogenic-shock rats improved, and the content of ATP and creatine phosphate in myocardium of these animals were restored by the treatment with 1 or 3 micrograms/kg/min of M6434.
"
4.
Shock
03/01/1989 - "
To elucidate the mechanisms of protective effect of M6434 on experimental shock, the authors examined the effects of this compound on the survival time and hemodynamic changes in severely hemorrhagic-shocked dogs.
"
01/01/1984 - "
These results indicate that M6434 may be evaluated as a possible therapeutic agent for shock.
"
03/01/1989 - "
M6434 (20 micrograms/kg/min) increased the venous return of dogs with cardiopulmonary bypass in both shock and normal state.
"
03/01/1989 - "
We also examined the effects of M6434 on contractile tension of isolated canine ventricular strips and on venous return in dogs with cardiopulmonary bypass in normal and shock state.
"
01/01/1984 - "
The effects of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434) were investigated in experimental models of lethal shock produced by hemorrhage, injection of endotoxin, or coronary ligation.
"
5.
Septic Shock (Toxic Shock Syndrome)
01/01/1984 - "
Effects of 2-[(5-chloro-2-methoxyphenyl)azo]-1H-imidazole (M6434) on hemorrhagic, cardiogenic, and endotoxin shock in rats and rabbits.
"
Related Drugs and Biologics
1.
Phosphocreatine (Neoton)
2.
Midodrine (Midon)
3.
Adenosine Triphosphate (ATP)
4.
Endotoxins
5.
Dopamine (Intropin)
6.
imidazole
Related Therapies and Procedures
1.
Ligation
2.
Cardiopulmonary Bypass (Heart-Lung Bypass)