alpha-fluoro-beta-alanine (FBAL)

01/01/2017 - "After hemodialysis for hyperammonemia, FBAL and FMA were collaterally decreased and his symptom was improved. "
01/01/2017 - "Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia."
01/01/2017 - "We found increases of serum FBAL and FMA under the condition of hyperammonemia in the patient with ESRD during mFOLFOX6 plus bevacizumab therapy. "
01/01/2017 - "Before onset of hyperammonemia encephalopathy, serum alpha-fluoro-beta-alanine (FBAL, 59.2 µg/ml) and fluoro mono acetate (FMA, 905.8 ng/ml) were gradually increased. "
11/01/2020 - "The blood concentrations of 5FU and its metabolites, α-fluoro-β-alanine (FBAL), and monofluoroacetate (FA) of a patient who had hyperammonemia from seven courses of palliative 5FU/LV therapy for gastric cancer were measured by liquid chromatography-mass spectrometry. "

04/20/2020 - "Conclusions: FBAL is effective in treating extremely severe burn patients combined with severe inhalation injury. "
04/20/2020 - "Objective: To explore the clinical effects of fiberoptic bronchoscopy airway lavage (FBAL) in the treatment of extremely severe burn patients with severe inhalation injury. "

05/01/2004 - "F but rather with FBAL levels in kidney (r=0.90, all treatments), indicating that uptake of liver-derived FBAL from the circulation is the major source of FBAL in tumor."
04/15/2000 - "FBAL did not affect the antitumor activity of FUra in mice bearing Colon 38 tumors. "
10/01/1996 - "In contrast to the PET data, no significant differences in the mean 5-[19F]FU and [19F]FBAL MR signal values in the tumor of both models were observed. "
01/01/1991 - "It was considered that the delayed catabolism to FBAL in the liver tumor group showed metabolic dysfunction of the liver. "
01/01/1999 - "The FBAL maps showed no FBAL accumulation in the hepatoma which reveals that the tumor cells have lost hepatocellular functions relevant for 5-FU catabolism. "

12/01/2005 - "The experience of this case, together with a review of the literature, suggests that FBAL is related to 5-FU-induced cardiotoxicity. "
01/01/1992 - "Recent studies have suggested that FUra catabolites, such as FBAL, may have a role in neurotoxicity and cardiotoxicity that may occur during FUra chemotherapy [Okada et al.: Acta Neuropathol. "
05/25/1993 - "It has been suggested previously that FBAL and/or its metabolites may have a role in the hepatotoxicity, neurotoxicity and cardiotoxicity resulting from FUra chemotherapy. "
12/01/2005 - "5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine."
12/01/2005 - "We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. "

01/01/2015 - "The objective of this work is to study how two of this antigens [actin (ACT) and fructose-bisphosphate aldolase (FBAL)] highly conserved in pathogens, activate fibrinolysis and to establish a relationship between this activation and the development of proliferative endarteritis during cardiopulmonary dirofilariasis. "