polyclonal B cell activator

factor found in alpha(2)-macroglobulin fraction of serum of patients with rheumatoid arthritis which produces polyclonal B cell activation; combination of rheumatoid factor & polyclonal B cell activator; titer provides a confidant laboratory measurement of disease involvement

Networked: 27 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bejarano, Maria Teresa: 2 articles (12/2009 - 09/2006)
2.	Donati, Daria: 2 articles (12/2009 - 09/2006)
3.	Wahlgren, Mats: 2 articles (12/2009 - 09/2006)
4.	Chene, Arnaud: 1 article (12/2009)
5.	Kironde, Fred: 1 article (12/2009)
6.	Mbidde, E R: 1 article (12/2009)
7.	Orem, Jackson: 1 article (12/2009)
8.	Guo, B: 1 article (06/2009)
9.	Rothstein, T L: 1 article (06/2009)
10.	Borrow, Ray: 1 article (05/2009)

Related Diseases

1.	Rheumatoid Arthritis 07/01/1985 - "Blood lymphocytes from 53 patients with rheumatoid arthritis (RA) and 44 controls were cultured with the polyclonal B cell activator Epstein-Barr virus (EBV). " 09/01/1984 - "In previous work a polyclonal B cell activator has been detected in the serum of patients with rheumatoid arthritis (RA). " 07/01/1981 - "The significance of polyclonal B cell activator in patients with rheumatoid arthritis." 01/01/1981 - "We investigated whether patients with rheumatoid arthritis have a polyclonal B cell activator (PBA) in their serum by using three methods: (1) the ability of any PBA to maintain the surface Ig of rabbit or human B cells in vitro; (2) the induction of blast transformation in human B lymphocyte cultures, and (3) stimulation of nude mouse spleen cells in vitro. " 01/01/1981 - "Polyclonal B cell activator associated with alpha-2-macroglobulin in the serum of patients with rheumatoid arthritis."
2.	Multiple Sclerosis 10/15/1984 - "In Gm3/Gm3 homozygous multiple sclerosis (MS) patients, in vitro production of the G1m(3) allotype of IgG1 induced by the T-independent polyclonal B-cell activator Salmonella paratyphi B (SPB) was lower than that of normal individuals of the same Gm phenotype. " 03/01/1986 - "Cerebrospinal fluid lymphocytes (CSF-L) and peripheral blood lymphocytes (PBL) from patients with multiple sclerosis (MS) and acute aseptic meningoencephalitis (AM) were cultured without and in the presence of pokeweed mitogen (PWM), a polyclonal B cell activator. "
3.	Malaria 09/01/2006 - "Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator." 12/01/2009 - "Following the observation of EBV reactivation in children living in malaria endemic areas and its relationship with acute malaria infection, we identified the cystein-rich inter-domain region 1 alpha (CIDR1 alpha) of the Plasmodium falciparum membrane protein 1 as a polyclonal B cell activator. "
4.	Infections 01/01/1987 - "aeruginosa infection at this timing depended on cooperation of macrophages and antibody which produced by stimulation of shosaiko-to, a polyclonal B cell activator. " 12/01/2009 - "Following the observation of EBV reactivation in children living in malaria endemic areas and its relationship with acute malaria infection, we identified the cystein-rich inter-domain region 1 alpha (CIDR1 alpha) of the Plasmodium falciparum membrane protein 1 as a polyclonal B cell activator. "
5.	Autoimmune Diseases (Autoimmune Disease) 01/01/1981 - "Characterization and role in autoimmune diseases of the polyclonal B-cell activator produced by T-cells-the helper factor." 06/01/2009 - "As Opn is a polyclonal B-cell activator that is strongly associated with a number of autoimmune diseases including lupus and rheumatoid arthritis, this novel finding is likely to be clinically relevant. "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Pokeweed Mitogens
3.	Immunoglobulin M (IgM)
4.	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
5.	Rheumatoid Factor
6.	Immunoglobulin G (IgG)
7.	Autoantibodies
8.	Interleukin-6 (Interleukin 6)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Thyroglobulin