HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

fodrin

comprised of two polypeptides (mol wt 250,000 & 240,000) axonally transported

Also Known As:

SPTAN1 protein, human; Spnb2 protein, mouse; alpha, gamma brain spectrin; alpha-fodrin; beta fodrin; betaII sigma1-spectrin; brain beta spectrin; non-erythroid beta spectrin; spectrin beta 2 protein, mouse; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) protein, human

Networked: 131 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hayashi, Yoshio: 7 articles (02/2008 - 05/2002)
2.	Hayashi, Y: 5 articles (06/2013 - 02/2001)
3.	Inserte, Javier: 5 articles (08/2010 - 10/2004)
4.	Garcia-Dorado, David: 5 articles (08/2010 - 10/2004)
5.	Shintani-Ishida, Kaori: 3 articles (08/2012 - 08/2005)
6.	Yoshikawa, Yoshiro: 3 articles (08/2010 - 04/2005)
7.	Takaki, Miyako: 3 articles (08/2010 - 04/2005)
8.	Taniguchi, Shigeki: 3 articles (08/2010 - 04/2005)
9.	Witte, Torsten: 3 articles (01/2009 - 03/2004)
10.	Shiari, Reza: 3 articles (02/2008 - 09/2005)

Related Diseases

1.	Ischemia 01/01/2009 - "Lowering perfusion flow to 50% during reperfusion cycles or shortening the cycles (12 cycles of 5 s ischemia-reperfusion) resulted in a further delay in pHi recovery (4.1 +/- 0.2 and 3.5 +/- 0.3 min, respectively), attenuated alpha-fodrin proteolysis, improved functional recovery, and reduced LDH release (47 and 38%, respectively, P < 0.001) and infarct size (36 and 32%, respectively, P < 0.001). " 08/01/2012 - "We previously showed that removal of PLN inhibition of SERCA2a with an antibody to (anti-) PLN reduces cytosolic Ca(2+) overload, thereby attenuating the spread of contraction bands and fodrin proteolysis, during reperfusion after cardiac ischemia. " 04/08/2005 - "Ischemia induced fodrin proteolysis in the ischemic core and the peri-infarct zone within 15 min after reperfusion, with proteolysis developing quickly in the ischemic core and more slowly in the peri-infarct zone. " 09/12/2003 - "Fifteen minutes after ischemia, proteolysis of fodrin took place in putamen, parietal cortex and hippocampal CA1. " 04/09/1999 - "Pronounced fodrin breakdown was observed in the cerebral cortex and striatum at 24 h after ischemia. "
2.	Fibrosis (Cirrhosis) 01/01/2011 - "We demonstrate that the administration of deferasirox, a tridentate iron chelator, is associated with diminished tissue iron deposition, attenuated activation of caspases, reduced α-fodrin cleavage, improved membrane integrity, decreased TUNEL reactivity, and attenuated cardiac fibrosis. " 01/01/2011 - "These iron-overload-induced alterations in Akt/Bad phosphorylation and Bax/Bcl-2 ratio were coupled with increased activation of the downstream caspase-9 (40/38- and 17-kDa fragments) and apoptosis executioner caspase-3 (19- and 17-kDa fragments), which were accompanied by evidence of elevated cytoskeletal α-fodrin cleavage (150- and 120-kDa fragments), discontinuity of myocardial membrane dystrophin immunoreactivity, increases in the number of terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells (nucleic DNA fragmentation), and cardiac fibrosis. "
3.	Brain Ischemia (Cerebral Ischemia) 03/01/1999 - "In the present study, we investigated species differences in the susceptibility of fodrin to calpain activation induced by cerebral ischemia in gerbils, rats, and mice. " 04/08/2005 - "In this study, we investigated the spatial distribution and temporal changes of calpain-catalyzed alpha-fodrin proteolysis in focal cerebral ischemia and examined the effects of a calpain inhibitor. "
4.	Sjogren's Syndrome (Sjogren Syndrome) 10/01/2005 - "Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome." 04/01/2005 - "Alpha-fodrin, an intracellular organ-specific cytoskeleton protein is a recently identified autoantigen associated with Sicca- and Sjogren's syndrome (SS). " 02/15/2005 - "The mice developed Sjogren's syndrome-like pathologic changes in the exocrine organs, and this was associated with autoimmunity against a ubiquitous protein, alpha-fodrin. " 05/01/2001 - "A cleavage product of alpha-fodrin may be an important organ-specific autoantigen in the pathogenesis of Sjogren's syndrome (SS), but the mechanisms of alpha-fodrin cleavage remain unclear. " 05/01/2001 - "Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome."
5.	Neoplasms (Cancer) 10/01/2008 - "The current study was carried out to investigate mechanisms by which embryonic liver fodrin (ELF), a crucial Smad3/4 adaptor, suppresses liver tumor formation. " 12/01/1989 - "Supranormal levels of fodrin at the apex of enterocytes were also observed in Crohn's disease samples and in the normal-appearing enterocytes adjacent to a tumor. " 01/01/2015 - "Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). " 03/23/2006 - "We found that embryonic liver fodrin (ELF), a beta-Spectrin originally identified in endodermal stem/progenitor cells committed to foregut lineage, possesses potent antioncogenic activity and is frequently inactivated in GI cancers. " 11/01/1992 - "Different organizational states of fodrin in cultured MDCK cells are induced by treatment with low pH, calmodulin antagonist TFP, and tumor promoter PMA."

Related Drugs and Biologics

1.	Caspases
2.	Iron
3.	deferasirox
4.	Calpain
5.	Antibodies
6.	Caspase 3 (Caspase-3)
7.	calpain inhibitors
8.	Immunoglobulin G (IgG)
9.	Immunoglobulin A (IgA)
10.	Cadherins (E-Cadherin)

Related Therapies and Procedures

1.	Intravitreal Injections
2.	Ligation
3.	Lenses
4.	Intravenous Infusions
5.	Induced Heart Arrest (Cardioplegia)