involucrin

soluble precursor protein of cross-linked envelope characteristic of epidermal s. corneum synthesized by keratinocytes in natural & cultured human epithelia; see also related records for prekeratin & stratum corneum basic protein precursor

Also Known As:

Networked: 224 relevant articles (2 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tam, Kimberley: 2 articles (04/2014 - 02/2014)
2.	Choolani, Mahesh: 2 articles (04/2014 - 02/2014)
3.	Zheng, Min: 2 articles (04/2014 - 07/2013)
4.	Biswas, Arijit: 2 articles (04/2014 - 02/2014)
5.	Chen, Jia-Qi: 2 articles (04/2014 - 07/2013)
6.	Bongso, Ariff: 2 articles (04/2014 - 02/2014)
7.	Fong, Chui-Yee: 2 articles (04/2014 - 02/2014)
8.	Huisman, Margriet A: 2 articles (04/2007 - 04/2006)
9.	De Heer, Emile: 2 articles (04/2007 - 04/2006)
10.	Grote, Jan J: 2 articles (04/2007 - 04/2006)

Related Diseases

1.	Periodontitis 09/01/2000 - "Semiquantitative immunohistochemical analysis revealed that in both clinically healthy gingiva and lesions of advanced periodontitis, expression patterns of E-cadherin, involucrin, and connexins 26 and 43 were similar, with a statistically significant reduction in staining intensity from the external oral epithelium, through the gingival sulcus, to the junctional epithelium or pocket epithelium, respectively. " 09/01/2000 - "In the different regions of lining epithelia from clinically healthy gingiva and periodontitis, comparisons were made of the expression patterns of E-cadherin, which is critical in intercellular adhesion; of proteins associated with gap junction communication channels; and of involucrin, which is a key marker of differentiation in stratified epithelia. "
2.	Breast Neoplasms (Breast Cancer) 01/01/1997 - "Both squamoid features and involucrin expression, which were considered to be derived either from differentiation into keratinocytes or from some kind of cellular degeneration caused by high turnover rate, are suggested to influence the biological behaviour of breast cancer cells in vivo, and they may be effective in predicting the most likely recurrence sites."
3.	Neoplasms (Cancer) 02/01/1988 - "This study confirmed this, further, the pattern of positive reaction of involucrin also indicated that this tumor is not of sweat duct origin." 01/01/2011 - "The expression level of ΔΝp63α was positively correlated with that of involucrin in cervical squamous cancer tissue, and the expression of ΔΝp63α is decreased with the degree of tumour invasion. " 01/01/2006 - "There existed a more powerful statistical difference regarding the histological grade between SCCs with the expression of both p27 and involucrin and tumors with other expression patterns (p = 0.0001). " 10/15/2003 - "The lack of correlation was because of heterogeneous patterns of immunostaining for involucrin generally related to tumor grade. " 01/01/1996 - "Involucrin and tumor progression in the uterine cervix."
4.	Carcinoma (Carcinomatosis) 01/01/1993 - "Involucrin expression in breast carcinomas: an immunohistochemical study." 01/01/1987 - "These studies suggest that involucrin will not differentiate between lesions of low versus high risk for progressing to invasive carcinoma. " 01/01/2006 - "Among well, moderately and poorly differentiated SCCs, 45.8 +/- 21.6, 20.0 +/- 15.0 and 10.6 +/- 9.1% of carcinoma cells expressed involucrin, respectively (p < 0.0001 for well vs. poorly, p < 0.0001 for well vs. moderately, and p = 0.042 for moderately vs. poorly). " 01/01/1996 - "Patterns of immunocytochemical staining for involucrin in cervical lesions of different grades, from low-grade to high-grade SILs, and invasive carcinoma may be of critical importance, if loss of involucrin expression is used as a criterion for neoplastic transformation in cervical epithelium. " 10/01/1994 - "Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin."
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/01/1987 - "[Immunohistochemical study of the localization of involucrin in squamous cell carcinoma: with special reference to its usefulness in the histological classification of severity and differential histological diagnosis]." 05/01/1985 - "Involucrin in intraepithelial and invasive squamous cell carcinomas of the cervix: an immunohistochemical study." 01/01/2006 - "Involucrin has been known as a marker of differentiation of squamous cell carcinoma (SCC). " 01/01/2006 - "Significance of immunohistochemical expression of p27 and involucrin as the marker of cellular differentiation of squamous cell carcinoma of the esophagus." 06/01/2004 - "[Significance of the Yamamoto-Kohama mode of invasion in the prognosis of esophageal squamous cell carcinoma: relationship with reduced expression of involucrin protein]."

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	Connexins
3.	Keratins (Keratin)
4.	Antibodies
5.	filaggrin
6.	Differentiation Antigens
7.	Proteins (Proteins, Gene)
8.	loricrin
9.	Proliferating Cell Nuclear Antigen (PCNA)
10.	Keratin-1

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)