barbituric acid (barbiturate)

10/01/2005 - "Monitoring for a therapeutic level of barbiturate coma includes targeting drug levels and using continuous electroencephalogram monitoring, considered the gold standard. "
11/01/1997 - "EEG and EP can provide an early indication of clinically relevant change due to evolving disease or in response to therapy, which is especially helpful when the neurologic examination is limited due to severe coma, therapeutic barbiturate coma, or neuromuscular blockade. "
02/01/1984 - "Although this study did not establish the possible effectiveness of barbiturate coma in improving residual neurologic damage after TCI, the data do demonstrate that any possible effectiveness in this model is not associated with any improvement in the markedly decreased cerebral perfusion after TCI."
10/22/2012 - "Several neuroprotective strategies such as barbiturate coma and hypothermic therapies have been promising in experimental studies but had limited efficacies in clinical trials. "
05/01/1992 - "This study reports all complications and side effects occurring in 38 patients with severe traumatic brain lesions treated with barbiturate coma because of a dangerous increase in intracranial pressure. "

01/01/1993 - "Retrospective analyses revealed that (a) over 90% of a group undergoing barbiturate taper maintained the same or improved seizure control and (b) some adults undergoing barbiturate tapers improved in target behaviors. "
11/01/1980 - "Barbiturate serum levels and protection against kindled amygdaloid seizures in the rat."
11/01/1982 - "As a seizure was observed in two of our cases after administration of this barbiturate, an EEG study was performed. "
08/01/2014 - "Administration of MIE was carried out prior to the exposure of a male Swiss mice to general behavioural tests, barbiturate sleep, PTZ-induced convulsion, light dark box (LDB), elevated plus maze (EPM), wire hanging, open field (OF) and forced swimming test (FST). "
04/01/2013 - "Seizures recurred on withdrawal of barbiturate anaesthetic until day 29. "

11/01/2000 - "Furthermore, mild hypothermia therapy provided the best functional outcome, which was not improved by additional barbiturate therapy. "
04/01/2011 - "Craniectomies (14 patients) were associated with good outcomes (GOS 4-5) in nine patients; hypothermia (six patients) and barbiturate (four patients) therapies were ineffective. "
02/01/1991 - "To improve the technical aspects of this procedure and to determine the optimum depth of hypothermia, the duration of arrest that can be tolerated, and the role of barbiturate brain protection, we conducted an experimental study on 11 baboons. "
03/01/2011 - "Hypothermia therapy was performed in 47%, positive normothermia therapy was administered in 76%, and barbiturate therapy was administered in 70%. "
09/01/2010 - "Hypothermia may obviate the need for potentially dangerous barbiturate therapy. "

01/01/1983 - "Barbiturate administration has been beneficial in some cases of sustained, uncontrolled intracranial hypertension. "
10/01/1999 - "The purpose of this study was to examine the changes in cerebral hemodynamics of head-injured patients undergoing barbiturate treatment of refractory intracranial hypertension. "
06/01/1994 - "The purpose of this study was to evaluate the role of barbiturate therapy as an adjunctive treatment for control of intracranial hypertension when conventional methods failed. "
11/01/2008 - "Barbiturate infusion for intractable intracranial hypertension and its effect on brain oxygenation."
01/01/2008 - "Hyperflow along with intracranial hypertension, variably responsive to barbiturate therapy, was observed in all the patients by means of TCD and CEO2. "

10/01/2009 - "Temperature management in studies of barbiturate protection from focal cerebral ischemia: systematic review and speculative synthesis."
10/01/2009 - "We reviewed all published reports evaluating barbiturate protection in animal models of focal cerebral ischemia where functional or anatomic endpoints were assessed. "
01/01/1999 - "EEG burst suppression is not necessary for maximum barbiturate protection in transient focal cerebral ischemia in the rat."
10/01/1990 - "Therapeutic window of CA1 neuronal damage defined by an ultrashort-acting barbiturate after brain ischemia in gerbils."
04/01/1987 - "[No indications for barbiturate therapy following complete cerebral ischemia. "