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dolastatin 1
from Indian Ocean sea hare Dolabella auricularia; structures given in first source
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
dolastatin 1: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
dolastatin 1: 1
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
Depsipeptides: 297
dolastatin 1: 1
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
Depsipeptides: 297
dolastatin 1: 1
Related Diseases
1.
Experimental Melanoma
07/01/1981 - "
The especially productive Indian Ocean sea hare Dolabella auricularia has yielded (100 kg leads to or approximately 1 mg each) a series of very potent cell growth inhibitory substances designated dolastatins 1-9. The first member of this new series, dolastatin 1, may represent the most potent anticancer agent so far uncovered with, e.g., a curative response (33%) using a dose of 11 microgram/kg (T/C 240, to T/C 139 at 1.37 microgram/kg) in the National Cancer Institute's murine B16 melanoma.
"
Related Drugs and Biologics
1.
Antineoplastic Agents (Antineoplastics)