1,N(6)-ethenodeoxyadenosine

Also Known As:

1,N(6)-deoxyethenoadenosine; 1,N2-etheno-2'-deoxyguanosine; 1,N6-etheno-2'-deoxyadenosine; 2'-deoxy-2-deuteroethenoadenosine; 3H-Imidazo(2,1-i)purine, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        Deoxyadenosines: 1
        1,N(6)-ethenodeoxyadenosine: 5
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - Deoxyadenosines: 1
        1,N(6)-ethenodeoxyadenosine: 5
  - Deoxyribonucleosides: 34
    - Deoxyadenosines: 1
      - 1,N(6)-ethenodeoxyadenosine: 5

Experts

1.	Bartsch, H: 2 articles (08/2000 - 04/2000)
2.	Nair, J: 2 articles (08/2000 - 04/2000)
3.	Di Mascio, Paolo: 1 article (01/2019)
4.	Falcão de Oliveira, Antonio Anax: 1 article (01/2019)
5.	Franco de Oliveira, Tiago: 1 article (01/2019)
6.	Gennari de Medeiros, Marisa Helena: 1 article (01/2019)
7.	Lemos, Miriam: 1 article (01/2019)
8.	Saldiva, Paulo Hilário Nascimento: 1 article (01/2019)
9.	Veras, Mariana: 1 article (01/2019)
10.	de Melo Loureiro, Ana Paula: 1 article (01/2019)

Related Diseases

1.	Carcinogenesis 08/01/2000 - "Formation of the lipoxygenase-catalyzed metabolites of arachidonic acid, 8-hydroxyeicosatetraenoic acid (8-HETE) and 12-hydroxyeicosatetraenoic acid (12-HETE), and of the exocyclic DNA adducts 1,N(6)-ethenodeoxyadenosine (epsilondA) and 3, N(4)-ethenodeoxycytidine (epsilondC) was investigated in NMRI mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). "
2.	Iron Overload 04/01/2000 - "Immunohistochemical detection of 1,N(6)-ethenodeoxyadenosine, a promutagenic DNA adduct, in liver of rats exposed to vinyl chloride or an iron overload." 04/01/2000 - "An immunohistochemical method was developed to localize the promutagenic 1,N(6)-ethenodeoxyadenosine DNA adduct in liver of rats exposed to vinyl chloride or an iron overload with or without carbon tetrachloride. "
3.	Neoplasms (Cancer) 01/01/2005 - "The increase in hepatocellular tumors occurred in a relatively linear manner and was attributed to the formation of 1,N(6)-ethenodeoxyadenosine in hepatic DNA coupled with an increase in cell replication. "
4.	Inflammation (Inflammations) 01/01/2019 - "Aldehydes and epoxyaldehydes resulting from the lipid peroxidation process are electrophilic molecules able to form mutagenic exocyclic DNA adducts, such as the etheno adducts 1,N2-etheno-2'-deoxyguanosine (1,N2-εdGuo) and 1,N6-etheno-2'-deoxyadenosine (1,N6-εdAdo), which have been suggested as potential biomarkers in the pathophysiology of inflammation. "
5.	Hepatolenticular Degeneration (Wilson's Disease) 06/01/2004 - "We now have investigated the levels of 1,N(6)-ethenodeoxyadenosine (epsilon dA) in human liver samples obtained from a group of patients diagnosed with hepatitis, fatty liver, fibrosis and cirrhosis, primary hemochromatosis and Wilson's disease. "

Related Drugs and Biologics

1.	DNA Adducts
2.	1,N(6)-ethenodeoxyadenosine
3.	Arachidonic Acid (Vitamin F)
4.	Biomarkers (Surrogate Marker)
5.	Vinyl Chloride (Chloroethylene)
6.	Lipoxygenase (Lipoxygenase-1)
7.	DNA (Deoxyribonucleic Acid)
8.	Carbon Tetrachloride (Tetrachloromethane)
9.	Aldehydes
10.	Acids