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n-octadecylphosphocholine

substrate analog for phospholipase A2

Also Known As:

ODPC; octadecylphosphocholine; Ethanaminium, 2-((hydroxy(octadecyloxy)phosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Choline: 6256
        Phosphorylcholine: 752
        n-octadecylphosphocholine: 6
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - Choline: 6256
      - Phosphorylcholine: 752
        n-octadecylphosphocholine: 6

Experts

1.	Dynarowicz-Łątka, Patrycja: 1 article (06/2013)
2.	Lątka, Kazimierz: 1 article (06/2013)
3.	Wnętrzak, Anita: 1 article (06/2013)
4.	Chin, Alice: 1 article (12/2012)
5.	Ciancaglini, Pietro: 1 article (12/2012)
6.	Falcão, Roberto P: 1 article (12/2012)
7.	Faça, Vitor M: 1 article (12/2012)
8.	Ferreira, Germano A: 1 article (12/2012)
9.	Greene, Lewis J: 1 article (12/2012)
10.	Hanash, Samir M: 1 article (12/2012)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2013 - "This work compared the interactions of selected APCs [namely, hexadecylphosphocholine (miltefosine), octadecylphosphocholine and erucylphosphocholine] with the most important membrane lipids [cholesterol, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)] and examined their influence on a model membrane of tumor and normal cells. " 09/01/1997 - "The cytotoxic interaction of two ether lipids, octadecylphosphocholine and ET-18-OCH3, and the chemotherapeutic drugs teniposide and paclitaxel on cancer cells in vitro was evaluated by use of a combined tetrazolium/formazan-labelled thymidine assay. "
2.	Leukemia 09/01/2010 - "Overall, the data indicate that ODPC acts on in vitro membrane systems and leukemia cell lines at concentrations below its CMC, suggesting that it does not act as a detergent and that this effect is dependent on membrane composition." 12/01/2012 - "We have shown that 25 μm 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate (ODPC), an alkylphospholipid, targets high cholesterol domains in model membranes and induces apoptosis in leukemia cells but spares normal hematopoietic and epithelial cells under the same conditions. "
3.	Occupational Diseases (Occupational Disease) 01/01/2011 - "The Occupational Disease Prevention and Control Act (ODPC-Act) of the People's Republic of China came into effect on May 1, 2002. "
4.	Carcinoma (Carcinomatosis) 01/01/1992 - "Hexadecylphosphocholine (HPC) and octadecylphosphocholine (OPC) show very potent antitumor activity against autochthonous methylnitrosourea-induced mammary carcinomas in rats. "

Related Drugs and Biologics

1.	Cholesterol
2.	miltefosine (Impavido)
3.	Paclitaxel (Taxol)
4.	Thymidine
5.	Teniposide (VM 26)
6.	Phosphates (Orthophosphate)
7.	Methylnitrosourea (N-Methyl-N-nitrosourea)
8.	Membrane Lipids
9.	Lipids
10.	Formazans