bis-netropsin

structure given in first source

Also Known As:

Dodecanediamide, N,N'-bis(2-((5-(((5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-propyl-1H-pyrrol-3-yl)amino)carbonyl)-1-propyl-1H-pyrrol-3-yl)amino)-2-oxoethyl)-, dihydrochloride

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Netropsin: 26
      - bis-netropsin: 1

Experts

1.	Bielawska, Anna: 1 article (01/2004)
2.	Bielawski, Krzysztof: 1 article (01/2004)
3.	Midura-Nowaczek, Krystyna: 1 article (01/2004)
4.	Pućkowska, Anna: 1 article (01/2004)

Related Diseases

Breast Neoplasms (Breast Cancer)

01/01/2004 - "We have investigated the cytotoxic activity of new aromatic analogues of DNA binding ligands in MCF-7 breast cancer cells and assessed their ability to act as inhibitors of topoisomerase I and II. These studies indicate that aromatic analogues of bis-netropsin contain two identical units tethered by alkyloxyl chains are a potent catalytic inhibitor of both topoisomerases and exhibit moderate cytotoxicity in MCF-7 breast cancer cells."

Related Drugs and Biologics

1.	Ligands
2.	Type I DNA Topoisomerases (Topoisomerase I)
3.	DNA (Deoxyribonucleic Acid)