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benzyloxycarbonylphenylalanylphenylalanine diazomethyl ketone
inhibits cathepsins B and L
Also Known As:
Z-Phe-Phe-CHN2; Z-Phe-PheCHN2; Carbamic acid, (2-((3-diazo-2-oxo-1-(phenylmethyl)propyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester, (S-(R*,R*))-
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Azo Compounds: 333
Diazonium Compounds: 3
Diazomethane: 26
benzyloxycarbonylphenylalanylphenylalanine diazomethyl ketone: 6
Related Diseases
1.
Infections
08/01/1999 - "
Immunostaining of H-2M within parasites was increased by treatment of infected macrophages with the cysteine protease inhibitors Z-Phe-AlaCHN2 or Z-Phe-PheCHN2 or by incubation of the parasites with the same inhibitors before infection.
"
10/01/1995 - "
This process was much more obvious if infected macrophages were incubated with protease inhibitors like antipain, chymostatin, Z-Phe-AlaCHN2 and Z-Phe-PheCHN2, or if amastigotes were pre-treated with the irreversible cysteine protease inhibitor Z-Phe-AlaCHN2 before infection, clearly indicating that amastigotes also degraded the internalized class II molecules.
"
2.
Periodontitis
08/01/1991 - "
The activities of cathepsin B- and L-like proteinases in homogenised gingival tissue from control and periodontitis patients were measured biochemically using the selective peptide substrate Z-Phe-Arg-AFC and the selective cathepsin L inhibitor Z-Phe-Phe-CHN2.
"
3.
Neoplasms (Cancer)
08/01/1997 - "
This enzyme is not inactivated by urea and Z-Phe-Phe-CHN2 and has a Michaelis constant (K(M) value) of approximately 1 mM. The specific characteristics suggest that it is a tumor-associated cathepsin B.
"
4.
Flushing
04/01/1991 - "
Optimum activity toward the substrate Z-Phe-Arg-NMec was observed at a pH of 5-6. Z-Phe-Phe-CHN2, a specific inhibitor of cathepsin L, significantly inhibited the proteolytic activity present in uterine flushings.
"
5.
Bone Resorption
08/30/1991 - "
Z-Phe-Phe-CHN2, a selective inhibitor of cathepsin L, at 1, 5, and 10 microM, inhibited bone resorption by rat osteoclasts 50, 85, and 100 per cent and, in chicken osteoclasts, cathepsin L activity was comparably inhibited.
"
Related Drugs and Biologics
1.
Cathepsin L
2.
Cysteine Proteinase Inhibitors
3.
Cathepsin B
4.
carbobenzoxyphenylalanine
5.
Urea (Carbamide)
6.
Protease Inhibitors (Protease Inhibitor)
7.
Peptides (Polypeptides)
8.
Peptide Hydrolases (Proteases)
9.
Enzymes
10.
Antipain