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bifemelane
structure given in first source
Also Known As:
2-(4-methylaminobutoxy)diphenylmethane; 4-(2-benzylphenoxy)-N-methylbutylamine; Celeport; MCI 2016; MCI-2016; bifemelane hydrochloride; 1-Butanamine, N-methyl-4-(2-(phenylmethyl)phenoxy)-, hydrochloride
Networked:
58
relevant articles (
7
outcomes,
5
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzhydryl Compounds
bifemelane: 58
Related Diseases
1.
Dementia (Dementias)
01/01/1991 - "
It is thus suggested that bifemelane hydrochloride is useful in the treatment of different symptoms of dementia.
"
01/01/1991 - "
The clinical effect of bifemelane hydrochloride on dementia in aged patients.
"
03/01/1991 - "
[Effect of the cerebro-metabolism activator (bifemelane hydrochloride) on urinary incontinence and pollakisuria associated with cerebrovascular dementia].
"
01/01/1991 - "
The effect of bifemelane hydrochloride on dementia in the elderly was studied in thirty-one patients having cerebrovascular disorders.
"
06/01/1993 - "
We suggested that amantadine and bifemelane could be particularly useful therapeutically when depressive symptoms are present in patients suffering from Parkinson's disease and dementia.
"
2.
Hypoxia (Hypoxemia)
07/01/1985 - "
After 5 days repeated administration, MCI-2016 significantly improved the decreased SMA due to hypoxia (rats) at 50 to 100 mg/kg, p.o.
"
12/01/1985 - "
Pretreatment of mice with 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) protected against effects of anemic hypoxia.
"
07/01/1985 - "
Effects of MCI-2016 on SMA changes were examined under several experimental conditions (normal conditions, hypoxia and head injury).
"
12/01/1985 - "
Pretreatment with bifemelane ameliorated the reduction in the synthesis of acetylcholine from labeled precursors in anemic hypoxia.
"
12/01/1985 - "
[Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on the synthesis of acetylcholine in anemic hypoxia].
"
3.
Cognitive Dysfunction
01/01/1988 - "
In accordance with these previous findings, our results suggest that bifemelane is useful in the treatment of memory loss and cognitive dysfunction in patients with dementia and cerebrovascular disease.
"
08/01/1994 - "
In the small number of studies available for evaluation, idebenone was generally superior to placebo and comparable with bifemelane, oxiracetam and nebracetam on the basis of a number of objective and subjective tests and rating scales in patients with mild to moderate cognitive decline.
"
4.
Cerebrovascular Disorders (Cerebrovascular Occlusion)
09/26/1994 - "
The effects of chronic administration of bifemelane (4-(2-benzylphenoxy)-N-methylbutylamine hydrochloride), which is used for the treatment of sequelae of cerebrovascular diseases, were also evaluated.
"
02/01/1986 - "
In summary, it may be suggested that MCI-2016 exhibits beneficial influences in the clinical fields of cerebrovascular diseases.
"
05/01/1983 - "
As a whole, these effects of MCI-2016 were superior to those of reference drugs for cerebrovascular diseases.
"
12/01/1994 - "
These results suggest that bifemelane might prevent the neuronal damage induced by ischemia and restore impaired learning and memory capabilities following cerebrovascular disease.
"
05/01/1994 - "
The effects of bifemelane hydrochloride on aphasia and on cerebral circulation and metabolism were studied using positron emission tomography (PET) in 10 aphasic patients with cerebrovascular disease.
"
5.
Brain Ischemia (Cerebral Ischemia)
10/01/1984 - "
[Protective effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on acutely induced cerebral ischemia in Mongolian gerbils and spontaneously hypertensive rats (SHR)].
"
12/01/1994 - "
After the RMP test, the hippocampal neuronal density following cerebral ischemia was observed histologically and the effect of bifemelane on it examined.
"
01/01/1994 - "
Protective effect of bifemelane on c-Fos-like immunoreactivity in rat cerebral ischemia.
"
09/01/1990 - "
The present results suggest that bifemelane may accelerate recovery of the pHi after cerebral ischemia.
"
11/01/1985 - "
These effects may participate in the protective effect of MCI-2016 on cerebral ischemia in Mongolian gerbils.
"
Related Drugs and Biologics
1.
Free Radicals
2.
Piracetam (Nootropil)
3.
Hydrogen Peroxide (Hydroperoxide)
4.
pramiracetam
5.
aniracetam
6.
bifemelane
7.
idebenone
8.
indeloxazine
9.
Cholinergic Agents (Cholinergics)
10.
nebracetam
Related Therapies and Procedures
1.
Autologous Transplantation
2.
Therapeutics
3.
Ligation
4.
Drug Therapy (Chemotherapy)
5.
Surgical Instruments (Clip)