gilvocarcin V

from Actinomycete DO-38; structure given in first source

Also Known As:

2064A; 4-fucofuranose-1-hydroxy-10,12-dimethoxy-8-vinyl-6H-benz(d)naphtho(1,2b)pyran-6-one; 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        gilvocarcin V: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        gilvocarcin V: 4
Carbohydrates: 22023
- Glycosides: 2119
  - gilvocarcin V: 4

Experts

1.	Cai, Xiao: 1 article (06/2014)
2.	Hertweck, Christian: 1 article (06/2014)
3.	Ishida, Keishi: 1 article (06/2014)
4.	Minehan, Thomas G: 1 article (06/2014)
5.	Moon, Seong-Jin: 1 article (06/2014)
6.	Ng, Kevin: 1 article (06/2014)
7.	Panesar, Harmanpreet: 1 article (06/2014)
8.	Paredes, Maria: 1 article (06/2014)
9.	Liu, Tao: 1 article (01/2011)
10.	Méndez, Carmen: 1 article (01/2011)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2011 - "Preliminary anticancer assays showed that D-olivosyl-gilvocarcin and polycarcin V exhibit antitumor activities comparable to that of their parent drug congener, gilvocarcin V, against human lung cancer (H460), murine lung cancer (LL/2), and breast cancer (MCF-7) cell lines. " 06/06/2014 - "The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the sequence features a stereoselective α-C-glycosylation reaction for the union of protected carbohydrate 7 and naphthol 8. The association constant for the binding of polycarcin V to duplex DNA is similar to that previously reported for gilvocarcin V. "
2.	Virus Diseases (Viral Diseases) 04/01/1994 - "Herpes virus infection and repair in cells pretreated with gilvocarcin V or merocyanine 540 and radiation."
3.	Sarcoma 180 06/01/1981 - "Gilvocarcin V, isolated rom a Streptomyces culture showed activity against experimental tumors such as sarcoma 180, Ehrlich carcinoma, Meth 1 fibrosarcoma, MH134 hepatoma and lymphocytic leukemia P388. "
4.	Neoplasms (Cancer) 06/01/1981 - "Gilvocarcin V, isolated rom a Streptomyces culture showed activity against experimental tumors such as sarcoma 180, Ehrlich carcinoma, Meth 1 fibrosarcoma, MH134 hepatoma and lymphocytic leukemia P388. "
5.	Melanoma (Melanoma, Malignant) 06/06/2014 - "The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the sequence features a stereoselective α-C-glycosylation reaction for the union of protected carbohydrate 7 and naphthol 8. The association constant for the binding of polycarcin V to duplex DNA is similar to that previously reported for gilvocarcin V. "

Related Drugs and Biologics

1.	polycarcin V
2.	Naphthols
3.	DNA (Deoxyribonucleic Acid)
4.	Carbohydrates
5.	merocyanine dye