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parathyroid hormone (3-34)
Also Known As:
bPTH (3-34); bovine parathyroid hormone (3-34); hPTH (3-34); parathyroid hormone (3-34), bovine; parathyroid hormone (3-34), human
Networked:
7
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Parathyroid Hormone: 11951
parathyroid hormone (3-34): 7
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Peptide Hormones: 1347
Parathyroid Hormone: 11951
parathyroid hormone (3-34): 7
Peptide Fragments: 373
parathyroid hormone (3-34): 7
Related Diseases
1.
Neoplasms (Cancer)
05/01/1988 - "
Bone resorption induced by tumor extract (1.35-fold stimulation) was inhibited by [Nle8,18,Tyr34]bPTH-(3-34) amide at concentrations of 5.0 and 1.0 microM.
"
05/01/1988 - "
At equivalent potency (1.80-fold stimulation of in vitro bone resorption) of tumor extract compared to bPTH-(1-34), [Nle8,18,Tyr34]bPTH-(3-34) amide (5.0 microM) was capable of significantly reducing in vitro bone resorption.
"
03/01/1983 - "
Both the adenylate cyclase-stimulating activity and cytochemical bioactivity are due to specific binding of a substance in the tumor extracts to renal PTH receptors, as demonstrated by competitive inhibition studies using the bovine PTH fragment analogue [Nle8,18, Tyr34]bPTH-(3-34) amide.
"
09/15/1990 - "
Tumor protein extracts stimulated cAMP production, which was inhibited by the PTH-antagonist (8,18 Nle, 34 Tyr)bPTH-(3-34)amide, in the PTH-responsive osteoblastic cell line UMR-106.
"
02/01/1987 - "
Extracts of the hypercalcemic tumor line (CAC-8) contained bone and kidney AC-stimulating activity which was enhanced by forskolin and dexamethasone, inhibited by [8,18Nle, 34Tyr]BPTH (3-34) amide, heat stable, trypsin sensitive, inactivated by reduction, and had a relative molecular weight of 34,000 by gel exclusion chromatography.
"
2.
Bone Resorption
05/01/1988 - "
Bone resorption induced by tumor extract (1.35-fold stimulation) was inhibited by [Nle8,18,Tyr34]bPTH-(3-34) amide at concentrations of 5.0 and 1.0 microM.
"
05/01/1988 - "
At equivalent potency (1.80-fold stimulation of in vitro bone resorption) of tumor extract compared to bPTH-(1-34), [Nle8,18,Tyr34]bPTH-(3-34) amide (5.0 microM) was capable of significantly reducing in vitro bone resorption.
"
05/01/1988 - "
Bone resorption induced by prostaglandin E2 (300 nM) was not inhibited by [Nle8,18,Tyr34]bPTH-(3-34) amide (5.0 microM).
"
05/01/1988 - "
A 1:2000-fold ratio of bPTH-(1-34) to [Nle8,18,Tyr34]bPTH-(3-34) amide significantly inhibited bone resorption induced by bPTH-(1-34); however, a 1:10,000 ratio completely antagonized bone resorption.
"
05/01/1988 - "
These data indicate that [Nle8,18,Tyr34]bPTH-(3-34) amide antagonizes in vitro bone resorption induced by bPTH-(1-34) in a dose-dependent manner and significantly inhibits bone resorption induced by the canine adenocarcinoma model of humoral hypercalcemia of malignancy.
"
3.
Wounds and Injuries (Trauma)
01/01/2023 - "
Herein, we developed a novel PTH analog, Human parathyroid hormone (hPTH) (3-34/29-34) (henceforth MY-1), by partially replacing and repeating the amino acid sequences of hPTH (1-34), and evaluated its effect on skin wound re-epithelialization.
"
4.
Adenocarcinoma
05/01/1988 - "
These data indicate that [Nle8,18,Tyr34]bPTH-(3-34) amide antagonizes in vitro bone resorption induced by bPTH-(1-34) in a dose-dependent manner and significantly inhibits bone resorption induced by the canine adenocarcinoma model of humoral hypercalcemia of malignancy.
"
5.
Humoral Hypercalcemia Of Malignancy
05/01/1988 - "
These data indicate that [Nle8,18,Tyr34]bPTH-(3-34) amide antagonizes in vitro bone resorption induced by bPTH-(1-34) in a dose-dependent manner and significantly inhibits bone resorption induced by the canine adenocarcinoma model of humoral hypercalcemia of malignancy.
"
Related Drugs and Biologics
1.
Amides
2.
Adenylyl Cyclases (Adenylyl Cyclase)
3.
bovine parathyroid hormone (1-34)
4.
Teriparatide (Parathar)
5.
Dinoprostone (PGE2)
6.
Trypsin
7.
Proteins (Proteins, Gene)
8.
Parathyroid Hormone (Parathormone)
9.
Hormones (Hormone)
10.
Colforsin