pumiliotoxin B

saturated indolizidine alkaloid from skin of panamanian frog Dendrobates pumilio; see also records for pumiliotoxin A, pumiliotoxin C & pumiliotoxins

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Del Pozo, Juan: 1 article (01/2019)
2.	Hoveyda, Amir H: 1 article (01/2019)
3.	Shi, Ying: 1 article (01/2019)
4.	Sun, Yu: 1 article (01/2019)
5.	Torker, Sebastian: 1 article (01/2019)
6.	Zhou, Yuebiao: 1 article (01/2019)
7.	Daly, John W: 1 article (07/2005)
8.	Fitch, Richard W: 1 article (07/2005)

Related Diseases

1.	Neuroblastoma 12/01/1992 - "The alkaloid pumiliotoxin B (PTX-B) "activates" voltage-dependent sodium channels in synaptoneurosomes and neuroblastoma cells. " 07/15/2005 - "Voltage-gated sodium channel-mediated (22)Na influx in a neuroblastoma cell line allowed assay of the effects of such sodium channel activators as batrachotoxin and a pumiliotoxin B/scorpion venom combination. "
2.	Neoplasms (Cancer) 01/01/2019 - "The utility of the approach is demonstrated by applications to concise preparation of the linear fragment of pumiliotoxin B (myotonic, cardiotonic) and enantioselective synthesis and structure confirmation of netamine C, a member of a family of anti-tumor and anti-malarial natural products. "
3.	Contracture 04/01/1985 - "Pumiliotoxin B (PTX-B, 6-(6',7'-dihydroxy-2',5'-dimethyl-(E)-4'-octenylidene)-8-hydroxy-8 -methyl-1- azabicyclo-[4.3.0] nonane) increases the force of contractures of spontaneously beating guinea pig atrial strips by 3- to 5-fold with half-maximal effects at about 3 microM and increases rates of atrial contractions by 2- to 3-fold with half-maximal effects at about 6 microM. "

Related Drugs and Biologics

1.	Sodium Channel Agonists
2.	Voltage-Gated Sodium Channels
3.	Sodium Channels (Sodium Channel)
4.	Scorpion Venoms (Scorpion Venom)
5.	Cardiotonic Agents (Cardiac Stimulants)
6.	Antimalarials (Antimalarial Agents)
7.	Alkaloids
8.	nonane