10-deacetyltaxol

alkaloid from Taxus wallichiana, structure given in first source

Also Known As:

10-deacetyl-7-epi-taxol; 10-deacetyl-7-epitaxol; Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        10-deacetyltaxol: 2
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        10-deacetyltaxol: 2

Experts

1.	Binscheck, T: 1 article (01/2012)
2.	Grobosch, T: 1 article (01/2012)
3.	Schwarze, B: 1 article (01/2012)
4.	Stoecklein, D: 1 article (01/2012)

Related Diseases

1.	Poisoning 01/01/2012 - "Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry."
2.	Neuroblastoma 02/01/1993 - "Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines." 02/01/1993 - "The cytotoxic effects of taxol, 10-deacetyltaxol, and cephalomannine at concentrations of 0.1 mug/ml to 10.0 mug/ml for one and 24 hours exposure were determined in two human glioblastoma multiforme and two neuroblastoma cell lines using the MTT method. "
3.	Neoplasms (Cancer) 02/01/1993 - "We conclude that tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range."
4.	Glioblastoma (Glioblastoma Multiforme) 02/01/1993 - "The cytotoxic effects of taxol, 10-deacetyltaxol, and cephalomannine at concentrations of 0.1 mug/ml to 10.0 mug/ml for one and 24 hours exposure were determined in two human glioblastoma multiforme and two neuroblastoma cell lines using the MTT method. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	cephalomannine
3.	baccatin III
4.	10-deacetylbaccatine III
5.	phloroglucinol dimethyl ether