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cimicifugoside

triterpene xyloside from Cimicifuga simplex; nucleoside transport inhibitor

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chikuma, Toshiyuki: 1 article (11/2009)
2.	Hojo, Hiroshi: 1 article (11/2009)
3.	Ito, Junko: 1 article (11/2009)
4.	Kato, Hanako: 1 article (11/2009)
5.	Kusano, Genjiro: 1 article (11/2009)
6.	Matsuhashi, Yuko: 1 article (11/2009)
7.	Uemura, Keiko: 1 article (11/2009)
8.	Yawata, Ayako: 1 article (11/2009)
9.	Baek, Woon-Yi: 1 article (05/2004)
10.	Jun, Dong-Jae: 1 article (05/2004)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 05/01/2004 - "We investigated the effect of the phytoestrogen cimicifugoside, one of the pharmacologically active ingredients of the medicinal plant Cimicifuga racemosa (black cohosh) that has been used to treat many kinds of neuronal and menopausal symptoms, such as arthritis, menopausal depression, and nerve pain. "
2.	Leukemia L1210 06/01/1981 - "Differential cytotoxicity of cytosine arabinoside toward murine leukemia L1210 cells and murine bone marrow progenitor cells inhibited in nucleoside transport by cimicifugoside." 06/01/1981 - "Cytotoxicities of cytosine arabinoside (Ara C) and showdomycin to murine L1210 leukemia cells was prevented by a nucleoside transport inhibitor, cimicifugoside. "
3.	Leukemia 11/05/2009 - "Cimicifugoside inhibited uptake of uridine, thymidine and adenosine in human leukemia U937 cells with the low nanomolar IC(50) values, but did not affect that of uracil, leucine or 2-deoxyglucose at <or=100 nM. Cimicifugoside analogs differentially inhibited uridine uptake in the order cimicifugoside>cimicifugenin (aglycon of cimicifugoside)>bugbanoside B>cimicifugenin A, O-methyl cimicifugenin and bugbanoside A. "
4.	Hypersensitivity (Allergy) 12/01/1980 - "The delayed type hypersensitivity to picryl chloride was suppressed after i.v. administration of cimicifugoside, 1.0-2.0 mg/mouse. "
5.	Carcinoma (Carcinomatosis) 11/05/2009 - "Cimicifugoside markedly potentiated methotrexate cytotoxicity in a culture of U937 cells and human carcinoma KB cells. "

Related Drugs and Biologics

1.	Phytoestrogens (Phytoestrogen)
2.	Uridine
3.	Uracil
4.	Thymidine
5.	Showdomycin
6.	Picryl Chloride (Trinitrochlorobenzene)
7.	Nucleosides
8.	Methotrexate (Mexate)
9.	Leucine (L-Leucine)
10.	Deoxyglucose (2 Deoxy D glucose)