HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

9-cis-retinal

Networked: 11 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Palczewski, Krzysztof: 5 articles (09/2021 - 05/2002)
2.	Maeda, Tadao: 3 articles (11/2011 - 05/2002)
3.	Kochman, Michał Andrzej: 1 article (09/2021)
4.	Kubas, Adam: 1 article (09/2021)
5.	Chen, Jianglei: 1 article (01/2020)
6.	Cheng, Rui: 1 article (01/2020)
7.	Ma, Jian-Xing: 1 article (01/2020)
8.	Malechka, Volha V: 1 article (01/2020)
9.	Moiseyev, Gennadiy: 1 article (01/2020)
10.	Dong, Zhiqian: 1 article (10/2018)

Related Diseases

1.	Fundus Albipunctatus 05/01/2010 - "A recent study of a mouse model of fundus albipunctatus treated with 9-cis-retinal showed an improvement in visual function and structure. " 10/01/2006 - "Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal."
2.	Retinal Degeneration 02/15/2016 - "Third, the retinal degeneration associated with the disruption of the visual cycle in Mitf-deficient mice can be partially corrected both structurally and functionally by an exogenous supply of 9-cis-retinal. " 01/01/2020 - "Overall, these findings showed that 9-cis-retinal administration restored visual pigment formation and decreased oxidative stress and retinal degeneration, which resulted in improved visual function in diabetic mice, suggesting that chromophore deficiency plays a causative role in visual defects in early DR." 11/01/2017 - "These results open new possibilities to use quercetin and other flavonoids, in combination with specific retinoids like 9-cis-retinal, for the treatment of retinal degeneration associated with retinitis pigmentosa. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/01/2020 - "Previous studies showed that the regeneration of 11-cis-retinal and visual pigment is impaired in a type 1 diabetes animal model, which negatively affects visual function at the early stage of DR. Here, Akita mice, type 1 diabetic model, were treated with the visual pigment chromophore, 9-cis-retinal. "
4.	Retinitis Pigmentosa (Pigmentary Retinopathy) 07/09/2010 - "We also demonstrate that W177R misfolding, unlike the P23H mutation in rod opsin that causes retinitis pigmentosa, is not rescued by treatment with the pharmacological chaperone 9-cis-retinal. " 11/01/2017 - "By using a combination of experimental and computational methods, we suggest that quercetin can act as an allosteric modulator of opsin regenerated with 9-cis-retinal and more importantly, that this binding has a positive effect on the stability and conformational properties of the G90V mutant associated with retinitis pigmentosa. " 11/01/2017 - "These results open new possibilities to use quercetin and other flavonoids, in combination with specific retinoids like 9-cis-retinal, for the treatment of retinal degeneration associated with retinitis pigmentosa. "
5.	Leber Congenital Amaurosis 11/01/2011 - "Therefore, treatment of mouse models of Leber congenital amaurosis with 9-cis-BC and 9-cis-retinyl-acetate, a well established 9-cis-retinal precursor, showed that the cis-carotenoid was far less effective than the cis-retinoid in rescuing vision. "

Related Drugs and Biologics

1.	Retinal Pigments (Pigments, Visual)
2.	Retinaldehyde (Retinal)
3.	Retinoids
4.	Opsins
5.	Rod Opsins
6.	Quercetin
7.	Ligands
8.	Flavonoids
9.	Carotenoids (Carotene)
10.	Aldehydes

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Oral Administration