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1- beta- arabinofuranosyl- 5- (2- chlorovinyl)uracil

selectively inhibits HSV-1 multiplication

Also Known As:

CV-ara-U; CV-araU; 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-chloroethenyl)-, (E)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 521
    - Pyrimidine Nucleosides: 50
      - Uridine: 1204
        Arabinofuranosyluracil: 37
        1-beta-arabinofuranosyl-5-(2-chlorovinyl)uracil: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6937
  - Pyrimidine Nucleosides: 50
    - Uridine: 1204
      - Arabinofuranosyluracil: 37
        1-beta-arabinofuranosyl-5-(2-chlorovinyl)uracil: 1
  - Arabinonucleosides: 1
    - Arabinofuranosyluracil: 37
      - 1-beta-arabinofuranosyl-5-(2-chlorovinyl)uracil: 1

Related Diseases

1.

07/01/1981 - "1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl) uracil (BV-ara-U) and 1-beta-D-arabinofuranosyl-E-5-(2-chlorovinyl)uracil (CV-ara-U) were tested for their anti-herpesviral activity in virus rating method, a plaque reduction method, and a virus yield reduction method, using human embryonic lung fibroblast (HEL-F) cells, At a concentration as low as 0.1 microgram/ml, both drugs exerted a marked inhibitory effect on the development of cytopathogenic effect induced by herpes simplex virus type 1 (HSV-1) infection and on the multiplication and plaque formation of HSV-1. "

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