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sorivudine

RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 8/90

Also Known As:

1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil; 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil; 5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil; BV-ara-U; BV-araU; brovavir; 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)-, (E)-

Networked: 39 relevant articles (7 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rady, Peter L: 1 article (07/2009)
2.	Satyaprakash, Anita K: 1 article (07/2009)
3.	Tyring, Stephen K: 1 article (07/2009)
4.	Mehta, Satish K: 1 article (07/2009)
5.	Mendoza, Natalia: 1 article (07/2009)
6.	Ravanfar, Parisa: 1 article (07/2009)
7.	Stelter, Arwen A: 1 article (07/2009)
8.	Pierson, Duane L: 1 article (07/2009)
9.	Tremaine, Anne Marie: 1 article (07/2009)
10.	Creed, Rosella: 1 article (07/2009)

Related Diseases

1.	Chickenpox 08/01/1996 - "The antiviral and clinical efficacy of sorivudine in adults with varicella was evaluated in a double-blind, placebo-controlled randomized trial. " 08/01/1996 - "Treatment of adult varicella with sorivudine: a randomized, placebo-controlled trial." 04/01/1992 - "In the present study, pharmacokinetic parameters and the efficacy of BV-araU against infection with simian varicella virus (SVV) were evaluated in African green monkeys. " 01/01/1993 - "Several new agents for varicella-zoster therapy are being evaluated; brovavir is a new agent currently being compared to placebo in the treatment of adult varicella." 03/01/1991 - "We evaluated the treatment of varicella-zoster infection with BV-araU in immuno-compromised patients with haematological malignancies in a randomized controlled study. "
2.	Herpes Zoster 07/01/2009 - "Sorivudine cream appears to be a safe and well-tolerated adjuvant therapy; however, further phase 2 studies are needed to determine its clinical efficacy for the treatment of herpes zoster. " 01/01/1990 - "A double-blind clinical study in patients with herpes zoster to establish YN-72 (Brovavir) dose." 05/01/1997 - "Sorivudine was given orally as 40 mg once-daily doses for 10 consecutive days to a total of 19 patients with herpes zoster. " 08/01/2002 - "In 1993, there were 18 acute deaths in Japanese patients who had the viral disease herpes zoster and were treated with the new antiviral drug sorivudine (SRV, 1-beta-D-arabinofuranosyl-(E)-5-(2-bromovinyl)uracil). " 01/01/1993 - "Several new agents for varicella-zoster therapy are being evaluated; brovavir is a new agent currently being compared to placebo in the treatment of adult varicella."
3.	Infection 05/01/1990 - "Thus, the antiviral efficacy of brovavir in mice was affected by the degree of virulence of the challenge virus strain used for infection." 01/01/1997 - "Both cellular uptake of [3H]BV-araU and its incorporation into the acid-insoluble fraction increased with increasing incubation time through 8 hr post-infection. " 01/01/1997 - "Approximately 10% of the total uptake of [3H]BV-araU was recovered from the acid-insoluble fraction at any time post-infection. " 08/01/1996 - "Sorivudine is a promising new agent for the treatment of varicella-zoster virus infections." 07/01/1996 - "Sorivudine has been studied in VZV infections. "
4.	HIV Infections (HIV Infection) 01/01/1996 - "Early indications from controlled studies, while not peer reviewed, indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection and chicken pox in adults. " 12/01/1995 - "Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection and adults with chicken pox. "
5.	Herpes Simplex 02/01/1992 - "Efficacy of oral treatment with BV-araU against cutaneous infection with herpes simplex type 1 in shaved mice."

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	sorivudine
3.	valacyclovir (valaciclovir)
4.	Uracil
5.	Fluorouracil (Carac)
6.	Prodrugs
7.	Carbon Monoxide
8.	Retinaldehyde (Retinal)
9.	Tegafur
10.	Cyclophosphamide (Cytoxan)

Related Therapies and Procedures

1.	Oral Administration
2.	Intravitreal Injections
3.	Aftercare (After-Treatment)