epomediol

marked choleretic activity in Wistar rats; mechanism of action may be related to increases in both the bile salt dependent & independent fractions of bile

Also Known As:

1,8-epoxy-1-methyl-4-isopropylcyclohexane-2,6-diol; Clesidren; 2-Oxabicyclo(2.2.2)octane-6,7-diol, 1,3,3-trimethyl-

Networked: 16 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - epomediol: 16
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - epomediol: 16

Experts

1.	Almar, M: 2 articles (08/2001 - 07/2000)
2.	Collado, P S: 2 articles (08/2001 - 07/2000)
3.	Cuevas, M J: 2 articles (08/2001 - 07/2000)
4.	Mauriz, J L: 2 articles (08/2001 - 07/2000)
5.	Almar, Mar: 1 article (03/2002)
6.	Cuevas, Maria Jose: 1 article (03/2002)
7.	González-Gallego, Javier: 1 article (03/2002)
8.	González-Gallego, J: 1 article (08/2001)
9.	El-Mir, M Y: 1 article (07/2000)
10.	Gonzalez-Gallego, J: 1 article (07/2000)

Related Diseases

1.	Pruritus (Itching) 05/01/1992 - "The beneficial effect of epomediol on pruritus in patients with ICP appeared greater in this study than that observed recently in similar patients who received a placebo." 05/01/1992 - "After epomediol administration was stopped, pruritus relapsed in 6 patients; 3 of them had received the higher drug dose. " 05/01/1992 - "A greater amelioration of pruritus was observed in patients treated with epomediol 1,200 mg/day than in patients who received 900 mg/day (to 20.7 +/- 6.2, as percent of pre-treatment severity score, versus 48.8 +/- 7.5 respectively; p < 0.05). " 05/01/1992 - "The severity of pruritus was significantly reduced in comparison to pretreatment status, with both doses of epomediol. " 09/01/1992 - "Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy."
2.	Intrahepatic Cholestasis of Pregnancy 09/01/1992 - "Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy." 05/01/1992 - "Assuming that the pathogenesis of intrahepatic cholestasis of pregnancy (ICP) is related with increased estrogen levels, we studied the effects of epomediol in this disease. "
3.	Cholestasis 05/01/1992 - "[Symptomatic effect of epomediol in patients with cholestasis of pregnancy]." 10/15/1989 - "Reversal of ethinylestradiol-induced cholestasis by epomediol in rat. " 08/01/1981 - "Effect of epomediol on bile flow and composition in normal rats and in rats with ethynylestradiol-induced cholestasis." 02/15/1983 - "[Epomediol-induced modifications of the biohumoral picture in hepatic cirrhosis with or without cholestasis]." 05/01/1992 - "Epomediol is a terpenoid that prevents and reverses cholestasis induced by ethinylestradiol in the rat, apparently by improving liver cell membrane fluidity. "
4.	Liver Diseases (Liver Disease) 05/01/1992 - "Biochemical parameters of liver dysfunction (serum bilirubin, bile salts, aminotransferase, alkaline phosphatases) were not modified during nor after epomediol administration. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 02/15/1983 - "[Epomediol-induced modifications of the biohumoral picture in hepatic cirrhosis with or without cholestasis]."

Related Drugs and Biologics

1.	Ethinyl Estradiol (Estinyl)
2.	Glutathione (Reduced Glutathione)
3.	Terpenes (Terpenoids)
4.	Therapeutic Uses
5.	Silymarin
6.	Bile Acids and Salts (Bile Acids)
7.	Glucuronides
8.	Ceftizoxime (Cefizox)
9.	Taurocholic Acid (Sodium Taurocholate)
10.	Phosphoric Monoester Hydrolases (Phosphatases)