pipecolic acid

RN given refers to cpd without isomeric designation

Also Known As:

2-piperidinecarboxylic acid; L-pipecolic acid; homopipecolic acid; pipecolic acid hydrochloride, (+-)-isomer; pipecolic acid, (+,-)-isomer; pipecolic acid, (-)-; pipecolic acid, (R)-isomer; pipecolic acid, (S)-isomer; pipecolic acid, 14C-labeled cpd, (+,-)-isomer; pipecolic acid, ion (1-); pipecolic acid, ion(1-), (+,-)-isomer; pipecolic acid, ion(1-), (S)-isomer; pipecolic acid, monopotassium salt

Networked: 114 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Pipecolic Acids
      - pipecolic acid: 114
- Heterocyclic Acids
  - Pipecolic Acids
    - pipecolic acid: 114

Experts

1.	Yuzyuk, Tatiana: 4 articles (01/2019 - 01/2016)
2.	Plecko, B: 4 articles (07/2018 - 07/2000)
3.	Gospe, Sidney M: 4 articles (11/2012 - 04/2006)
4.	Jakobs, Cornelis: 3 articles (11/2012 - 07/2004)
5.	Jakobs, C: 3 articles (06/2005 - 07/2000)
6.	Wevers, Ron A: 2 articles (11/2021 - 10/2005)
7.	van Karnebeek, Clara D M: 2 articles (11/2021 - 11/2012)
8.	Gong, Pan: 2 articles (01/2019 - 01/2019)
9.	Jiang, Shiju: 2 articles (01/2019 - 01/2019)
10.	Jiang, Yuwu: 2 articles (01/2019 - 01/2019)

Related Diseases

1.	Zellweger Syndrome (Zellweger's Syndrome) 01/01/1980 - "Biochemical studies in the cerebro-hepato-renal syndrome of Zellweger: a disturbance in the metabolism of pipecolic acid." 10/01/1993 - "cerebralhepatorenyl (Zellweger) syndrome (CHRS) contained little D-pipecolic acid. " 05/01/1989 - "Thus, the high circulating levels of L-pipecolic acid in Zellweger syndrome probably result from defective peroxisomal oxidation of L-pipecolic acid to AAA." 05/01/1989 - "L-pipecolic acid oxidation in normal infant livers was low at birth and increased with age, but Zellweger syndrome livers showed little activity at any age. " 05/01/1989 - "Peroxisomal L-pipecolic acid oxidation is deficient in liver from Zellweger syndrome patients."
2.	Seizures (Absence Seizure) 06/01/2005 - "Determination of pipecolic acid in plasma and/or CSF should be included in the diagnostic work-up of patients with therapy-resistant seizures. " 12/01/2021 - "We observed a neurodevelopmental improvement, significantly fewer seizures, and a reduction of pipecolic acid (PA) as a biomarker of the illness. " 04/01/2006 - "Levels of both pipecolic acid and certain metabolites shown to be elevated in patients with PNPO mutations should be measured, and therapeutic trials of pyridoxal phosphate as well as pyridoxine should be considered early in the course of the management of infants and young children with intractable seizures." 10/30/2009 - "Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures." 07/01/2018 - "Data were analyzed regarding ALDH7A1 mutations, alpha-Aminoadipic semialdehyde (α-AASA) and pipecolic acid (PA) levels, medication during pregnancy, delivery, treatment delay, amount of seizures, pyridoxine dose, adjuvant therapy and findings on brain MRI. "
3.	Carcinogenesis 08/01/2022 - "Together, this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse, presented evidence for refining parenteral nutrition composition, and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis."
4.	Neoplasms (Cancer) 08/01/2022 - "Together, this study revealed a panel of 12 ESCC tumor-associated serum metabolites with potential for monitoring therapeutic efficacy and disease relapse, presented evidence for refining parenteral nutrition composition, and highlighted serum pipecolic acid as an attractive biomarker for predicting ESCC tumorigenesis."
5.	Peroxisomal Disorders (Peroxisomal Disorder) 01/01/2001 - "Biochemical studies revealed elevation of blood pipecolic acid and VLCFAs, compatible with peroxisomal disorder. " 07/01/2004 - "For all patients, pipecolic acid proved to be a useful parameter in the biochemical classification of peroxisomal disorders." 12/01/2002 - "Mild to moderate elevations of pipecolic acid were frequently found in non-peroxisomal disorders and this should be taken into account when interpreting the laboratory data." 02/14/1992 - "The utility of the method was demonstrated by quantitating pipecolic acid in biological fluids derived from patients with peroxisomal disorders. " 05/01/1989 - "We measured L-pipecolic acid oxidation in liver specimens from patients with peroxisomal disorders. "

Related Drugs and Biologics

1.	pipecolic acid
2.	Pyridoxine (Pyridoxin)
3.	Biomarkers (Surrogate Marker)
4.	Lysine (L-Lysine)
5.	Leucovorin (Folinic Acid)
6.	Anticonvulsants (Antiepileptic Drugs)
7.	Fatty Acids (Saturated Fatty Acids)
8.	Acids
9.	Proteins (Proteins, Gene)
10.	Phytanic Acid

Related Therapies and Procedures

1.	Parenteral Nutrition
2.	Therapeutics
3.	Treatment Delay