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1,1,1,2-tetrachloroethane

see also record for tetrachloroethane

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - 1,1,1,2-tetrachloroethane: 3
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Ethane: 225
        1,1,1,2-tetrachloroethane: 3

Related Diseases

1.	Carcinogenesis 05/01/1983 - "Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CAS: 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)." 05/01/1983 - "Carcinogenesis studies of technical grade 1,1,1,2-tetrachloroethane (>99% pure) were conducted by administering the test chemical in corn oil by gavage to groups of 50 male and 50 female F344/N rats at doses of 125 or 250 mg/kg body weight and to groups of 50 male and 50 female B6C3F1 mice at doses of 250 or 500 mg/kg. (1,1,1,2-tetrachloroethane is used as a chemical intermediate in the production of trichloroethylene and tetrachloroethylene). "
2.	Neoplasms (Cancer) 05/01/1983 - "Under the conditions of these studies, 1,1,1,2-tetrachloroethane was not demonstrated to be carcinogenic in F344/N rats, although the observed increase in the proportion of male rats with liver tumors may have been associated with the administration of 1,1,1,2-tetrachloroethane; accidental killing of 27 male and 15 female rats reduced the sensitivity of this bioassay for detecting a carcinogenic response. "
3.	Body Weight (Weight, Body) 05/01/1983 - "Carcinogenesis studies of technical grade 1,1,1,2-tetrachloroethane (>99% pure) were conducted by administering the test chemical in corn oil by gavage to groups of 50 male and 50 female F344/N rats at doses of 125 or 250 mg/kg body weight and to groups of 50 male and 50 female B6C3F1 mice at doses of 250 or 500 mg/kg. (1,1,1,2-tetrachloroethane is used as a chemical intermediate in the production of trichloroethylene and tetrachloroethylene). "
4.	Liver Cell Adenoma (Hepatocellular Adenoma) 05/01/1983 - "1,1,1,2-Tetrachloroethane was carcinogenic for B6C3F1 mice, causing an increased proportion of female mice with hepatocellular carcinomas and an increased proportion of male and female mice with hepatocellular adenomas; the decreased survival in high-dose male and female mice compromised the ability of this bioassay to further determine the presence or absence of a carcinogenic effect and gave clear evidence that these doses were toxic. "
5.	Polyploidy 08/12/1996 - "Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloroethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy). "

Related Drugs and Biologics

1.	Trichloroethylene (Trichloroethene)
2.	Tetrachloroethylene (Tetrachloroethene)
3.	Corn Oil (Oil, Corn)
4.	tetrachloroethane
5.	chlorendic acid
6.	chlorodibromomethane
7.	bromodichloromethane
8.	ethylene dichloride (1,2-dichloroethane)
9.	pentachloroethane
10.	isophorone